Simulation of roller compaction using a laboratory scale compaction simulator

Influence of Ambient Moisture on the Compaction Behavior of Microcrystalline Cellulose Powder Undergoing Uni-Axial Compression and Roller-Compaction: A Comparative Study Using Near-Infrared Spectroscopy

“…Feed rate of the powder was kept constant by fixing the horizontal feed screw (HFS) speed at 30 rpm and vertical speed screw (VFS) speed at 200 rpm. Compacts were prepared at 5,6,7,8,9, and 10 rpm roll speeds. At each roll speed compaction was carried out for 4 min and a single strip of compact ribbon, at least 65 cm in length ($circumference of the rolls), was collected at the end of the 3rd min and immediately cut into 16 segments, each 4 cm in length, using a surgical knife.…”

“…Despite widespread use, the effect of the densification of powder undergoing roller compaction is poorly understood, although a number of authors have attempted to model this process. [5][6][7] Recently, Zinchuk et al 8 have reported the use of a compaction simulator to prepare simulated ribbons under different compression pressure. They found good agreement between the physical and mechanical properties of the simulated ribbons and the roller compacted samples.…”

Examining the Impact of Excipient Material Property Variation on Drug Product Quality Attributes: A Quality-By-Design Study for a Roller Compacted, Immediate Release Tablet

“…At a solid fraction of 0.65, the tensile strength of the batches containing low particle size MCC is ∼0. 15 MPa higher relative to the batches containing high particle size MCC. This observed difference was confirmed in Table 8, in which the tensile strength of batches 10 and 11 were 0.17 and 0.15 MPa greater (p < 0.05) than batches 4 and 5, respectively, for similar solid fraction values (i.e., 0.636-0.642).…”

Roller Compaction, Granulation and Capsule Product Dissolution of Drug Formulations Containing a Lactose or Mannitol Filler, Starch, and Talc

“…where SF is the solid fraction (i.e., relative density) of ribbons; ρ e is the envelope density of ribbons; ρ o is the true density of the granules milled from ribbons (18). The true density of granulated materials was determined using a helium pycnometer (UltraPycnometer® 1000, Quantachrome Corporation, Boynton Beach, FL, USA).…”