The geological conditions of the Three Gorges Reservoir Region are complex and changing, and large- and medium-sized landslides are widely distributed. When a high-speed moving landslide enters the water, the water is significantly disturbed, and a landslide-generated wave will be formed, which will spread along the upstream and downstream of the river, causing significant threats and destruction to the hydraulic structures and the navigation of ships. Based on the typical rock landslide parameters and fracture development, we establish a three-dimensional physics experimental model of the bending section of the landslide-generated wave in the Three Gorges Reservoir Region. This paper primarily studies the variation law of the first wave height of landslide-generated waves with the width, height, and water entry velocity of the landslide body and then provides an empirical formula for the first wave height of landslide-generated waves in the curved section of the Three Gorges Reservoir Region. The ship rolling motion equation in the landslide-generated water area is analysed and established systematically. Additionally, the ship manoeuvring motion model in the landslide-generated water area is built. This paper explains the variation characteristics of ship turning tracks at different sailing speeds and sailing positions and proposes a basis to determine the navigation safety of ships in this area, thus providing new theoretical and technical support for the risk assessment of navigation of ships in the reservoir area.