Simulation of magnetic nanoparticles crossing through a simplified blood-brain barrier model for Glioblastoma multiforme treatment

Gkountas, Apostolos A.; Polychronopoulos, Nickolas D.; Sofiadis, George; Karvelas, Evangelos; Spyrou, Leonidas A.; Sarris, Ioannis E.

doi:10.1016/j.cmpb.2021.106477

Cited by 15 publications

(7 citation statements)

References 48 publications

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“…The source of the magnetic field can be a cylindrical rare-earth (NdFeB) magnet [ 163 , 164 ], including a magnet implanted subdermally [ 165 ] or placed under the culture plate [ 166 , 167 ], and a circular Halbach array composed of eight NdFeB magnets [ 168 ]. The strength of the applied magnetic field is reported in the range of 0.01–1.0 T [ 165 , 167 , 169 ]. Additionally, to the static magnetic field, the dynamic magnetic field produced by rotating NdFeB magnets (60 rpm) can be applied [ 168 ].…”

Section: Physical Methods Of Histohematic Barriers Permeability Enhan...mentioning

confidence: 99%

Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

et al. 2023

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Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic (i.e., theranostic) potencies in translational oncology, and some agents have been further translated into clinical trials. However, the practical application of nanoparticle-based medicine in living organisms is limited by physiological barriers (blood–tissue barriers), which significantly hampers the transport of nanoparticles from the blood into the tumor tissue. This review focuses on several approaches that facilitate the translocation of nanoparticles across blood–tissue barriers (BTBs) to efficiently accumulate in the tumor. To overcome the challenge of BTBs, several methods have been proposed, including the functionalization of particle surfaces with cell-penetrating peptides (e.g., TAT, SynB1, penetratin, R8, RGD, angiopep-2), which increases the passing of particles across tissue barriers. Another promising strategy could be based either on the application of various chemical agents (e.g., efflux pump inhibitors, disruptors of tight junctions, etc.) or physical methods (e.g., magnetic field, electroporation, photoacoustic cavitation, etc.), which have been shown to further increase the permeability of barriers.

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Section: Physical Methods Of Histohematic Barriers Permeability Enhan...mentioning

confidence: 99%

Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

et al. 2023

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“…Besides, more MNP accumulation in the mouse brain was observed when applying an alternating magnetic field, demonstrating its ability to modulate BBB permeability through the magnetic guidance of NPs. 138 Gkountas et al 139 demonstrated that an EMF could significantly enhance MNP delivery across the BBB. Without EMF exposure, 100 nm MNPs showed minimal BBB penetration (2−6%).…”

Section: 23mentioning

confidence: 99%

“…This demonstrates that EMF intensity and fluid dynamics modulate MNP delivery across the BBB, providing insights into enhancing brain nanoparticle permeation via magnetic guidance. 139 The third strategy is to utilize the heat produced by Neél relaxation of magnetic NPs under the radiofrequency field, which can also transiently and locally open the BBB. 2,140 5.2.5.…”

Section: 23mentioning

confidence: 99%

“…At a baseline flow of 10 –3 m/s, the percentage of NPs passing the BBB reached 45%, decreasing to 32% under slow flow (5 × 10 –4 m/s) but improving slightly to 48% with faster flow (2 × 10 –3 m/s). This demonstrates that EMF intensity and fluid dynamics modulate MNP delivery across the BBB, providing insights into enhancing brain nanoparticle permeation via magnetic guidance . The third strategy is to utilize the heat produced by Néel relaxation of magnetic NPs under the radiofrequency field, which can also transiently and locally open the BBB. , …”

Section: Permeation Mechanisms Of Nanoparticles Capable Of Crossing T...mentioning

confidence: 99%

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Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Zha,

Liu,

et al. 2024

ACS Nano

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The blood−brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels. Thus, the BBB also prevents the passage of various forms of therapeutic agents, nanocarriers, and their cargos. Recently, many multidisciplinary studies focus on developing cargo-loaded nanoparticles (NPs) to overcome these challenges, which are emerging as safe and effective vehicles in neurotheranostics. In this Review, first we introduce the anatomical structure and physiological functions of the BBB. Second, we present the endogenous and exogenous transport mechanisms by which NPs cross the BBB. We report various forms of nanomaterials, carriers, and their cargos, with their detailed BBB uptake and permeability characteristics. Third, we describe the effect of regulating the size, shape, charge, and surface ligands of NPs that affect their BBB permeability, which can be exploited to enhance and promote neurotheranostics. We classify typical functionalized nanomaterials developed for BBB crossing. Fourth, we provide a comprehensive review of the recent progress in developing functional polymeric nanomaterials for applications in multimodal bioimaging, therapeutics, and drug delivery. Finally, we conclude by discussing existing challenges, directions, and future perspectives in employing functionalized nanomaterials for BBB crossing.

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“…Another study created a geometrical model that employed computational fluid dynamics to predict blood flow behavior with injected magnetic nanoparticles under various conditions, such as blood flow fluctuations. This provided information on the permeability of the BBB [ 221 ]. One more study used three-compartment cellular modeling (apical, cell monolayer, and basolateral) and statistical approaches to successfully simulate the time course of drug cellular uptake and accumulation, based on its BBB passive permeability, in order to demonstrate the functional relevance of uptake and efflux transporters to BBB penetration of drugs [ 222 ].…”

Section: Computational Modeling Of Gbm: New Insights Toward Understan...mentioning

confidence: 99%

Understanding Glioblastoma Signaling, Heterogeneity, Invasiveness, and Drug Delivery Barriers

Rabah,

Ait Mohand,

Kravchenko-Balasha

2023

IJMS

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The most prevalent and aggressive type of brain cancer, namely, glioblastoma (GBM), is characterized by intra- and inter-tumor heterogeneity and strong spreading capacity, which makes treatment ineffective. A true therapeutic answer is still in its infancy despite various studies that have made significant progress toward understanding the mechanisms behind GBM recurrence and its resistance. The primary causes of GBM recurrence are attributed to the heterogeneity and diffusive nature; therefore, monitoring the tumor’s heterogeneity and spreading may offer a set of therapeutic targets that could improve the clinical management of GBM and prevent tumor relapse. Additionally, the blood–brain barrier (BBB)-related poor drug delivery that prevents effective drug concentrations within the tumor is discussed. With a primary emphasis on signaling heterogeneity, tumor infiltration, and computational modeling of GBM, this review covers typical therapeutic difficulties and factors contributing to drug resistance development and discusses potential therapeutic approaches.

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Simulation of magnetic nanoparticles crossing through a simplified blood-brain barrier model for Glioblastoma multiforme treatment

Cited by 15 publications

References 48 publications

Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Understanding Glioblastoma Signaling, Heterogeneity, Invasiveness, and Drug Delivery Barriers

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