Simulation of impact on cardiovascular events due to lipid-lowering therapy intensification in a population with atherosclerotic cardiovascular disease

Lipid Control Post Coronary Artery Bypass Graft: One Year Follow-Up of a Middle-Eastern Cohort

“…New studies have also demonstrated the importance of statin treatment intensification for optimal protection against cardiovascular events in a population with ASCVD. It was shown in the simulation of impact that in a real-world scenario, 818 ASCVD patients in a cohort of 1000 would require treatment intensification with lipid-lowering therapies, resulting in 29 events avoided over 5 years [11,15,16].…”

“…Despite these guidelines and evidence-based studies, compliance and optimization of treatment is poor, with a very high percentage of patients still not achieving the recommended lipid targets [16]. ASCVD remains an epidemic both globally and regionally, as the Middle-East continues to have one of the highest cardiovascular disease associated mortalities in the world [17].…”

Simulation of anticoagulation in atrial fibrillation patients with rivaroxaban—from trial to target population

“…It is known that DES is a strategy for modeling disease pathway and outcomes over time as a function of treatment and patient-level covariates [9]. Several studies have used DES to simulate LLT in patients with atherosclerotic cardiovascular disease [14,15,24]. Besides, a recent study used baseline characteristics from two observational studies to replicate the efficacy and safety of dabigatran compared to warfarin in the RE-LY study with a DES model [25].…”

“…Using DES, we could generalize the results to real-world patients with a different distribution of characteristics from the RCT population. Previous studies [14,15] have used DES to estimate the percentage of patients with atherosclerotic cardiovascular disease who would require lipid-lowering therapy (LLT) intensification in real practice and evaluate the impact of LLT intensification on cardiovascular events. In this study, we proposed a DES to predict the counterfactual outcomes of ROCKET AF that would have been conducted in larger observational study populations.…”

Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness

“…Hypertriglyceridemia and high cholesterol levels are related to atherosclerosis [2,41], and current mathematical models estimate that lipid-lowering therapies could avoid a substantial number of cardiovascular events [42]. Among the different dietary supplements proposed for lipid-lowering treatment, Mg has been used not only to prevent cardiovascular events in patients suffering from chronic kidney disease [43], but also for metabolic syndrome treatment [44] as well as to improve cardiovascular health in overweight and obese people [45].…”