Simulation of coronary capillary transit time based on full vascular model of the heart

Review of cardiac–coronary interaction and insights from mathematical modeling

“…The 0D-lumped parameter models are the most simplified and computationally inexpensive approach for describing blood flow and pressure dynamics in the cardiovascular system, especially when modeling the entire coronary system or large-scale circulatory networks. These models are formulated based on a set of ordinary differential equations (ODEs) to represent the overall behavior of blood flow and pressure in discrete compartments such as individual vessels or segments Fan, Namani, Choy, Awakeem, et al, 2021;Fan et al, 2022;Pagoulatou et al, 2021;Munneke et al, 2022;Namani et al, 2020;Wang et al, 2024). For example, mass conservation in each vessel i within a circulation network requires…”

Preconditioning with selective autoretroperfusion: In vivo and in silico evidence of washout hypothesis

“…A validated computer model of the coronary artery-capillaryvein network and an indicator-tracking approach (Wang et al, 2024) (Supplementary Material) were used to test the washout mechanism of SARP. Briefly, this computer model considers the Frontiers in Bioengineering and Biotechnology frontiersin.org coronary arteries, veins (including Thebesian veins), and capillaries, as well as their interactions with the heart in a closed-loop system (Supplementary Figure S1).…”

“…To simulate the SARP procedure, the large coronary artery and the distal GCV are occluded, as indicated by the black crosses, and pulsatile femoral pressure is applied to the area proximal to the GCV (Supplementary Figure S1). The indicator-tracking approach (Wang et al, 2024) was used to evaluate the efficiency of metabolite washout from occluded regions to the heart's chambers via Thebesian veins, in the context of SARP. In this method, indicators (representing metabolites) are "virtually" released at various locations (e.g., arterioles of order 1, a larger artery of order 7, or a vein of order −7).…”

“…The model parameters are determined and calibrated based on our previous studies (Fan et al, 2020;Fan et al, 2021;Wang et al, Frontiers in Bioengineering and Biotechnology frontiersin.org 2024). Using this set of model parameters, the predictive accuracy of the model for blood pressure and flow rate distributions has been validated through comparison with other computational studies (Wang et al, 2024). The particle-tracking approach used in the computational model has also been validated against experimental measurements (Wang et al, 2024).…”

“…Using this set of model parameters, the predictive accuracy of the model for blood pressure and flow rate distributions has been validated through comparison with other computational studies (Wang et al, 2024). The particle-tracking approach used in the computational model has also been validated against experimental measurements (Wang et al, 2024).…”