“…The relevance of this approach is limited by the completeness of the database used. Other attempts have tried to improve the quality of the conformational maps by including various energy terms (Lakshminarayanan & Sasisekharan, 1969;Sasisekharan & Lakshminarayanan, 1969;Govil & Saran, 1971a,b;Saran & Govil, 1971;Kim et al, 1973;Newton, 1973;Saran et al, 1973a,b;Yathindra & Sundaralingam, 1973;Perahia et al, 1974a,b;Tewari 1974;Govil, 1976;Levitt & Warshel, 1978;Srinivasan et al, 1980;Poltev et al, 1981;Tosi & Lipari, 1981;Pattabiraman & Langridge, 1985;Pearlman & Kim, 1985, 1986b, 1988Gabb & Harvey, 1993;Girlado et al, 1998). Computational limitations continue to prevent comprehensive searching using energy criteria, limiting the signi®cance of the constructed maps to special cases or to model compounds.…”