Simulation of action potential in cardiomyocytes

Ivanko, K.; Ivanushkina, N.; Prokopenko, Yuriy

doi:10.1109/elnano.2017.7939777

Cited by 4 publications

(5 citation statements)

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“…Simulated action potentials for ventricular and atrial cardiomyocytes (Fig. 1) were obtained in [22]. In accordance with the theoretical information [20] each action potential has three characteristic phases: depolarization, plateau and repolarization.…”

Section: Action Potentials and Main Currents For Cardiomyocytessupporting

confidence: 57%

“…The proposed model [22] accounts for main ionic currents and change of potential for cell's membrane. Independent conductance channels are used for + , + , 2+ and leakage.…”

Section: Computational Modelingmentioning

confidence: 99%

“…A detailed description of the functions and numerical values for parameters of the proposed model is given in [22].…”

Section: +mentioning

confidence: 99%

“…According to the proposed model [22], currents and conductances for potassium, sodium, calcium ions were calculated and presented for ventricular cardiomyocytes in Fig. 2b-d…”

Section: Action Potentials and Main Currents For Cardiomyocytesmentioning

confidence: 99%

“…Simulated action potentials for ventricular and atrial cardiomyocytes. Modified from[22]. Arrows indicate the time point of 90% of AP duration (APD90).…”

mentioning

confidence: 99%

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A Computational Model of Electrophysiological Properties of Cardiomyocytes

Ivanushkina

Іванько

Prokopenko

et al. 2018

Visnyk NTUU KPI Seriia - Radiotekhnika Radioaparatobuduvannia

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The method of electrical analogies for the analysis of bioelectric dynamic processes in cardiomyocytes is used in the study. This method allows for replacing investigation of phenomena in nonelectrical systems by research of analogous phenomena in electrical circuits. The investigation of time processes in cardiac cells is based on the solution of the system of ordinary differential equations for an electrical circuit. Electrophysiological properties of cardiomyocytes such as refractory period, maximum capture rate and electrical restitution are studied. Mathematical modeling. Computational simulation of the action potential and currents for + , + , 2+ ions in cardiomyocytes is performed by using the parallel conductance model. This model is based on the assumption of the presence of independent ion channels for + , + , 2+ ions, as well as leakage through the membrane of cardiac cell. Each branch of the electrical circuit reflects the contribution of one type of ions to total membrane current. Results.The obtained electrical restitution curves for ventricular and atrial cardiomyocytes are presented in the paper. The proposed model makes it possible to identify the areas with the maximum slope on the restitution curves, which are crucial in the development of cardiac arrhythmias. Dependences of calcium current on stimulation frequency for atrial and ventricular cardiomyocytes are obtained. Analysis of the kinetics of calcium ions under various protocols of external influences can be useful for predicting the contractile force of cardiomyocytes. Conclusion.The results of calculations can be used to interpret the experimental results obtained in investigations of cardiomyocytes using the "laboratory on a chip" technology, as well as in the design of new experiments with cardiomyocytes for drug screening, cell therapy and personalized studies of heart diseases.

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Section: Action Potentials and Main Currents For Cardiomyocytessupporting

confidence: 57%

“…The proposed model [22] accounts for main ionic currents and change of potential for cell's membrane. Independent conductance channels are used for + , + , 2+ and leakage.…”

Section: Computational Modelingmentioning

confidence: 99%

“…A detailed description of the functions and numerical values for parameters of the proposed model is given in [22].…”

Section: +mentioning

confidence: 99%

“…According to the proposed model [22], currents and conductances for potassium, sodium, calcium ions were calculated and presented for ventricular cardiomyocytes in Fig. 2b-d…”

Section: Action Potentials and Main Currents For Cardiomyocytesmentioning

confidence: 99%

“…Simulated action potentials for ventricular and atrial cardiomyocytes. Modified from[22]. Arrows indicate the time point of 90% of AP duration (APD90).…”

mentioning

confidence: 99%

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