Sustainable Manufacturing entails a transition from traditional processes -namely production, delivery and marketing, to new business models based on a commitment toward a reduction on the social and environmental business impact, while engaged in rising competitiveness and eco-nomic value for the company. A global, rising, commitment comes from governments and individuals, while Industry 4.0 technologies seem to support best this transition. In Italy, during the first half of the 2020, the perspective on the future suddenly changed forcing individuals, busi-nesses and governments to rethink their lives on a completely different schema due to the emergency of the Pandemic. Since the second semester, the global economy started to recover from the huge fall during the rough days of the Covid-19 and businesses ran to fill the gap of the first se-mester, facing unexpected rise in raw materials €™ prices and new pressures to curb global warm-ing, stressing the more and more individuals, businesses and global economies to adopt a re-sponsible attitude. This work offers an overview of the state-of-the-art on a huge business area, the Lombardy region â€"one of the leading in the European Union and proactively devoted to Sus-tainable manufacturing transition.