The transition to Industry 4.0 poses new challenges for sensor integration design. The foundation of any intelligent system is the data and the data quality depends largely on the integration of the sensor generating it. In this study, the barriers for robust sensor system design are explored through an interview study among practitioners from different industrial contexts. The aim was to explore potential challenges within different contexts and suggest possible directions for research within the field of sensor integration design. It is highlighted that there is a need for multi-disciplinary tools based on synthesis of basic knowledge across relevant engineering domains, like mechanical, electrical and software.