Simulation Analysis of Blood Flow in Arteries of the Human Arm

Wu, Quanyu; Liu, Xiaojie; Pan, Lingjiao; Tao, Weige; Cui, Qian

doi:10.4015/s1016237217500314

Cited by 14 publications

(15 citation statements)

References 21 publications

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“…Our results have the same order of magnitude as previous works [31,[35][36][37]. For instance, Choudhari and Panse obtained a radial deformation ranging from 1.5 to 2.2 µm and a maximal velocity about 0.6 m/s.…”

Section: Resultssupporting

confidence: 89%

Numerical Study of the Blood Flow in a Deformable Human Aorta

2019

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In this work, we present a numerical investigation of blood flow in a portion of the human vascular system. More precisely, the present work analyzed the blood flow in the upper portion of the aorta. The aorta and its ramified blood vessels are surrounded by the cardiac muscle. The blood flow generates pressure on the internal surfaces of the artery and its ramifications, thereby causing deformation of the cardiac muscle. The numerical analysis used the Navier–Stokes equations as the governing equations of blood flow for the calculation of the velocity field and pressure distribution in the blood. The neo-Hookean hyperelastic model was used for the description of the behavior of the vessel walls. The velocity and pressure distributions were analyzed. The deformation of the vessel was also investigated. The numerical results could be used to better understand and predict the factors that trigger cardiovascular diseases and distortions of the aorta and as a diagnostic tool in clinical applications.

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Section: Resultssupporting

confidence: 89%

Numerical Study of the Blood Flow in a Deformable Human Aorta

2019

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“…To estimate the range of stress inside the mandible at E60, we used ANSYS 15.0 to establish the cup model, in which a “cup” mimics the U‐shaped mandible slice (Fig F–H; Quanyu et al , ). In this model, the open ends of the cup were expanded as simulated stress was applied to the inner wall (Fig G and H).…”

Section: Resultsmentioning

confidence: 99%

Biomechanical stress regulates mammalian tooth replacement via the integrin β1‐RUNX2‐Wnt pathway

et al. 2019

The EMBO Journal

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Renewal of integumentary organs occurs cyclically throughout an organism's lifetime, but the mechanism that initiates each cycle remains largely unknown. In a miniature pig model of tooth development that resembles tooth development in humans, the permanent tooth did not begin transitioning from the resting to the initiation stage until the deciduous tooth began to erupt. This eruption released the accumulated mechanical stress inside the mandible. Mechanical stress prevented permanent tooth development by regulating expression and activity of the integrin b1-ERK1-RUNX2 axis in the surrounding mesenchyme. We observed similar molecular expression patterns in human tooth germs. Importantly, the release of biomechanical stress induced downregulation of RUNX2-wingless/integrated (Wnt) signaling in the mesenchyme between the deciduous and permanent tooth and upregulation of Wnt signaling in the epithelium of the permanent tooth, triggering initiation of its development. Consequently, our findings identified biomechanical stress-associated Wnt modulation as a critical initiator of organ renewal, possibly shedding light on the mechanisms of integumentary organ regeneration.

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“…Before ANSYS analysis, the material parameters were set as follows: the blood density and viscosity were set to be constant at 1060 kg/m 3 and 3.5 × 10 −3 Pa•s, respectively [24,25]. The blood flow was set to no heat exchange and laminar flow.…”

Section: Resultsmentioning

confidence: 99%

Influence of malformation of right coronary artery originating from the left sinus in hemodynamic environment

Cong

Qiu

et al. 2020

BioMed Eng OnLine

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Background: The anomalous origin of the right coronary artery (RCA) from the left coronary artery sinus (AORL) is one of the abnormal origins of the coronary arteries. Most of these issues rarely have any effects on human health, but some individuals may exhibit symptoms, such as myocardial ischemia or even sudden death. Recently, researchers have investigated the AORL through clinical cases, but studies based on computational fluid dynamics (CFD) have rarely been reported. In this study, the hemodynamic changes between the normal origin of the RCA and the AORL are compared based on numerical simulation results. Methods: Realistic three-dimensional (3D) models of the 16 normal right coronary arteries and 26 abnormal origins of the RCAs were constructed, respectively. The blood flow was numerically simulated using the ANSYS software. This study used a one-way fluid-solid coupling finite element model, wherein the blood is assumed to be an incompressible Newtonian fluid, and the vessel is assumed to be made of an isotropic linear elastic material. Results: The cross-sectional area differences between the inlet of the normal group and that of the abnormal group were significant (P < 0.0001). Moreover, there were significant differences in the volumetric flow (P = 0.0001) and pressure (P = 0.0002). Positive correlation exists for the ratio of the cross-sectional area of the RCA to the inlet area of the ascending aorta (AAO), and the ratio of the inlet volumetric flow of the RCA to the volumetric flow of the AAO, in the normal (P = 0.0001, r = 0.8178) and abnormal (P = 0.0033, r = 0.6107) groups. Conclusion: This study demonstrates that the cross-sectional area of the AORL inlet may cause ischemia symptoms. The results obtained by this study may contribute to the further understanding of the clinical symptoms of the AORL based on the hemodynamics.

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Simulation Analysis of Blood Flow in Arteries of the Human Arm

Cited by 14 publications

References 21 publications

Numerical Study of the Blood Flow in a Deformable Human Aorta

Numerical Study of the Blood Flow in a Deformable Human Aorta

Biomechanical stress regulates mammalian tooth replacement via the integrin β1‐RUNX2‐Wnt pathway

Influence of malformation of right coronary artery originating from the left sinus in hemodynamic environment

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