“…Co-metabolism is a traditional approach adopted to enhance the degradation of refractory pollutants and CH 4 production in the anaerobic digestion system, which can vigorously promote the growth and activity of indigenous microbes by supplying some popular carbon sources (e.g., glucose, fructose, and sucrose) for microbes to the target system ( Li et al, 2016a , b ; Xie et al, 2016 ; Khan et al, 2017 ; Hadibarata et al, 2018 ; Feng et al, 2019 ). Glucose is one of the most favorable carbon (energy) sources for heterotrophic microbes and has been frequently used as a co-metabolic substrate to improve CH 4 production and accelerate the degradation of refractory pollutants in diverse environments ( Ambrosoli et al, 2005 ; Jing et al, 2017 ; Khan et al, 2017 ; Shu et al, 2021 ; Zhou et al, 2021 ). For example, the addition of glucose was found to significantly enhance the degradation of fluorene, phenanthrene, and pyrene under an anaerobic denitrification system ( Ambrosoli et al, 2005 ), and the addition of glucose effectively alleviated the inhibitory effect of gallic acid on CH 4 production in an anaerobic digestion system ( Mousa and Forster, 1999 ).…”