Despite the long R&D history of interactive minimally-invasive surgery and therapy simulations, the guidewire/catheter behavior modeling remains challenging in Percutaneous Coronary Intervention (PCI) surgery simulators. This is primarily due to the heterogeneous heart physiological structures and complex intravascular inter-dynamic procedures. To ameliorate, this paper advocates a novel, robust, and efficient guidewire/catheter modeling method based on heterogeneous and integrated chain-mails, that can afford medical practitioners and trainees the unique opportunity to experience the entire guidewire-dominant PCI procedures in virtual environments as our model aims to mimic what occurs in clinical settings. Our approach's originality is primarily founded upon this new method's unconditional stability, realtime performance, flexibility, and high-fidelity realism for guidewire/catheter simulation. Considering the front end of the guidewire has different stiffness with its conjunctive slender body and the guidewire length is adaptive to the surrounding environment, we propose to model the spatially-varying sixdegree of freedom behaviors by solely resorting to the generalized 3D chain-mails. Meanwhile, to effectively accommodate the motion constraints caused by the beating vessels and flowing blood, we integrate heterogeneous volumetric chainmails to streamline guidewire modeling and its interaction with surrounding substances. By dynamically coupling guidewire chain-mails with the surrounding media via virtual links, we are capable of efficiently simulating the collision-involved interdynamic behaviors of the guidewire. Finally, we showcase a PCI prototype simulator equipped with haptic feedback for mimicing the guidewire intervention therapy, including pushing, pulling, and twisting operations, where the built-in high-fidelity, real-time efficiency, and stableness show great promise for its practical applications in clinical training and surgery rehearsal fields.