2006
DOI: 10.1016/j.compbiomed.2005.06.002
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Simulating chemotherapeutic schemes in the individualized treatment context: The paradigm of glioblastoma multiforme treated by temozolomide in vivo

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Cited by 18 publications
(12 citation statements)
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“…Also, it may help in developing specific optimal fractionation schemes for selected patient subgroups. However, despite its enormous potential, mathematical modelling has had a very limited use with strong focus on some aspects of radiation therapy (RT) for high-grade gliomas [49,50,51,52,53,54]. Up to now, no ideas coming from mathematical modelling have been found useful for clinical application in any of these contexts.…”
Section: Radiotherapy Of Low Grade Gliomasmentioning
confidence: 99%
“…Also, it may help in developing specific optimal fractionation schemes for selected patient subgroups. However, despite its enormous potential, mathematical modelling has had a very limited use with strong focus on some aspects of radiation therapy (RT) for high-grade gliomas [49,50,51,52,53,54]. Up to now, no ideas coming from mathematical modelling have been found useful for clinical application in any of these contexts.…”
Section: Radiotherapy Of Low Grade Gliomasmentioning
confidence: 99%
“…A simulation model of tumor response to other treatment modalities, such as chemotherapy has already been presented by our group (Stamatakos et al 2005). The chemotherapy model presented in this article provides a theoretical support for the observed superiority of the standard administration schedule of the Temozolomide agent commonly used to treat glioblastoma multiforme.…”
Section: Resultsmentioning
confidence: 99%
“…Simulating Chemotherapeutic Schemes for Individualization A novel patient individualized, spatiotemporal Monte Carlo simulation model of tumor response to chemotherapeutic schemes in vivo has been described (Stamatakos et al 2006 ). Treatment of GBM by temozolomide is considered as a paradigm.…”
Section: Molecular Determinants Of Response To Egfr Inhibitorsmentioning
confidence: 99%