Simulated moving bed process with cyclic modulation of the feed concentration

Schramm, H.; Kaspereit, Malte; Kienle, Achim; Seidel‐Morgenstern, A.

doi:10.1016/s0021-9673(03)00327-3

Cited by 105 publications

(50 citation statements)

References 13 publications

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“…1d, while keeping the flow-rates and the column configuration unchanged. It was demonstrated that by cyclic modulation of the feed concentration the productivity can be increased and the eluent consumption can be reduced in a nonlinear separation system; the advantage of ModiCon over SMB was also validated experimentally [Schramn et al, 2003].…”

Section: Comparison Of the Smb Varicol Powerfeed And Modicon Processesmentioning

confidence: 97%

“…Recently, we have been able to verify experimentally in the case of a chiral separation that the PowerFeed process can indeed outperform the SMB process [Zhang et al, 2004]. A third new SMB operation mode, ModiCon, has recently been proposed [Schramn et al, 2002[Schramn et al, , 2003, which is based on the concept of modulating the feed concentration of the SMB process during the switching period, as shown in Fig. 1d, while keeping the flow-rates and the column configuration unchanged.…”

Section: Comparison Of the Smb Varicol Powerfeed And Modicon Processesmentioning

confidence: 99%

“…In fact, there is a clear trend in applications to operate SMB with 5 or 6 columns, instead of 8, which was previously regarded as the minimum number of columns for SMB units. The second approach aims at improving the unit's separation efficiency either by optimizing the adsorptivity of the solutes in the different sections of the unit, such as in supercritical fluid SMB [Nicoud and Perrut, 1992;Mazzotti et al, 1997b;Di Giovanni et al, 2001;Denet et al, 2001], temperature gradient SMB [Migliorini et al, 2001] and solvent gradient SMB [Jensen et al, 2000;Antos and Seidel-Morgenstern, 2001;Abel et al, 2002;Houwing et al, 2003], or more recently by operating SMB under more complex dynamic conditions, as it is the case in the Varicol Zhang et al, 2002Zhang et al, , 2003aToumi et al, 2003;Pais and Rodrigues, 2003], PowerFeed [Kearney and Hieb, 1992;Kloppenburg and Gilles, 1999;Zang and Wankat, 2002a, b;Zhang et al, 2003bZhang et al, , 2004 and ModiCon [Schramn et al, 2002[Schramn et al, , 2003 processes. These new operation modes do not keep constant conditions during one switching period t * , as in a standard SMB, but allow for variation of the column configuration, the fluid flowrates, or the feed concentration, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Continuous chromatographic processes with a small number of columns: Comparison of simulated moving bed with Varicol, PowerFeed, and ModiCon

Zhang

Mazzotti

Morbidelli

2004

Korean J. Chem. Eng.

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‡ This paper is dedicated to Professor Hyun-Ku Rhee on the occasion of his retirement from Seoul National University. The importance of the seminal papers of Professor Rhee on first order partial differential equations and the theory of multicomponent chromatography (H. are studied, in the case where a small number of columns are used, i.e. from three to five. A multiobjective optimization approach, using genetic algorithms and a detailed model of the multicolumn chromatographic process, is applied to optimize each process separately, and allow for comparison of the different operating modes. The non-standard SMB processes achieve better performance than SMB, due to the availability of more degrees of freedom in the operating conditions of the process, namely the way to carry out asynchronous switches for Varicol, and the different flow rates and feed concentration during the switching interval for PowerFeed and for ModiCon, respectively. We also consider the possibility of combining two non-standard operating modes in a new hybrid process, and evaluate also in this case the possible performance. Finally, a critical assessment of the results obtained and of the potential for practical implementation of the different techniques is reported.-

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Section: Comparison Of the Smb Varicol Powerfeed And Modicon Processesmentioning

confidence: 97%

Section: Comparison Of the Smb Varicol Powerfeed And Modicon Processesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Continuous chromatographic processes with a small number of columns: Comparison of simulated moving bed with Varicol, PowerFeed, and ModiCon

Zhang

Mazzotti

Morbidelli

2004

Korean J. Chem. Eng.

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“…Further modifications of the simulating moving bed techniques are: the PowerFeed SMB process (Kearney and Hieb, 1992;Kloppenburg and Gills, 1999;Zhang et al, 2003aZhang et al, , 2004a in which the flow rates in the unit are allowed to change during a column switching time following a predefined pattern; in Varicol (Adam et al, 2000, Hombourger et al, 2000Zhang et al, 2002Zhang et al, , 2003bToumi et al, 2003;Pais and Rodrigues, 2003) the basic principle of the process consists of an asynchronous shift of the inlet/outlet lines in a system of multicolumns in a recycle loop; in ModiCon (Schramn et al, 2002(Schramn et al, , 2003, another modification of classical SMB, the flow rate and the column configuration are kept unchanged while modulating the feed concentration during the switching period of the SMB process. Schematic representations of these three processes, i.e., PowerFeed, Varicol and ModiCon, in comparison to the basic SMB system, are shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Simulation assessment of continuous simulating moving bed chromatography process with partial feed and new strategy with partial feed

Khan

2009

Braz. J. Chem. Eng.

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-Partial Feed simulating moving bed (SMB) has proved to be more efficient in binary separation performance (purity, recovery, productivity) because of its two additional degrees of freedom, namely feed length and feed time, as compared to classical SMB process. The binary separation of dextran T 6 and fructose with linear isotherm is modeled with Aspen Chromatography simulator in a four zone SMB with one column per zone for both normal-feed and Partial Feed. Increase in number of feed length and feed time in the cycle plays a very important role in the separation performance with Partial Feed. In addition, the effect of mode of operation (early or late introduction of increase in number of feed length in the cycle) on product purity and recovery is also investigated. Furthermore, the binary separation system is designed with the safety margin method and the optimum operating parameters for simulation are calculated with triangle theory. Finally, a new strategy with Partial Feed is developed, showing improved separation performance relative to the basic four-zone SMB with regard to extract stream purity and recovery. The results of the proposed study can served as a useful summary of Partial Feed operation.

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“…As a result, relatively inefficient columns may be used in SMB yielding satisfactory separation. Recently, more sophisticated modes of operation have been proposed, such as the Varicol (Subramani et al, 2003), ModiCon (Schramm et al, 2002) and Powerfeed (Zhang et al, 2003), which essentially derive from the conventional SMB just described, providing higher resolution and general superior performance.…”

Section: Introductionmentioning

confidence: 99%

Design and optimization of new simulated moving bed plants

Azevedo

Rodrigues

2006

Braz. J. Chem. Eng.

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-The simulated moving bed (SMB) technology has attracted considerable attention for its efficiency as a chromatographic adsorptive separation. It has been increasingly applied to the separation of binary mixtures with low separation factors, namely to separate isomers. Although quite a vast amount of information has been published concerning the simulation and design of operating conditions of existing SMB plants, fewer works have addressed the question of design and optimisation of geometric parameters and operating conditions of a new adsorber, especially when mass transfer resistances are significant. The present work extends an algorithm developed elsewhere to design SMB equipment and optimize its operating conditions and applies it to the case of fructose-glucose separation using a cation-exchange resin as stationary phase in order to obtain nearly pure fructose in the extract and glucose in the raffinate. The constraints were set as 99% purity for both products. The objective function was chosen to be the adsorbent productivity. The algorithm attempted to find the minimum column lengths for increasing throughputs, which met the required purity constraint. Then, the best construction parameters and operating conditions were chosen as those for which the adsorbent productivity was maximum. The effects of the safety margins applied on the velocity ratios in sections 1 and 4 were examined and a heuristic rule for optimum eluent flowrate was derived. The effect of the purity requirements was also investigated. Finally, the calculated optimal operating points, in terms of flowrate ratios in SMB sections 2 and 3, were analysed in the frame of the equilibrium theory. Sound coherence was verified, which confirmed the accuracy and adequacy of the extended algorithm for the design and optimisation of a SMB adsorber with strong mass transfer effects.

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Simulated moving bed process with cyclic modulation of the feed concentration

Cited by 105 publications

References 13 publications

Continuous chromatographic processes with a small number of columns: Comparison of simulated moving bed with Varicol, PowerFeed, and ModiCon

Continuous chromatographic processes with a small number of columns: Comparison of simulated moving bed with Varicol, PowerFeed, and ModiCon

Simulation assessment of continuous simulating moving bed chromatography process with partial feed and new strategy with partial feed

Design and optimization of new simulated moving bed plants

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