Simulated moving bed chromatography for the separation of enantiomers

Rajendran, Arvind; Paredes, Galatea; Mazzotti, Marco

doi:10.1016/j.chroma.2008.10.075

Cited by 346 publications

(237 citation statements)

References 134 publications

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“…In zones 2 and 3, the separation takes place, while zones 1 and 4 are required for the regeneration of the stationary and mobile phase, respectively. 489,495,496 In particular the TMB, enhances the mass transfer driving force, allowing a better use of the adsorbent and permitting increased productivity values (higher processed throughput using less packing material). The TMB also permits the achievement of high-purity products, even in the cases of low resolution (reduced selectivity) as well as less dilute product streams, and thus enables reduced solvent recovery duty (eluent/desorbent), which is the opposite of traditional batch elution chromatography.…”

Section: Basic Smb Principlesmentioning

confidence: 99%

“…484 For this reason, a higher affinity solute (turtle) migrates more slowly than a low-affinity solute (cat), resulting in separation of the various feed components in the column. 484,489 It is generally difficult to achieve high product purity and high yield simultaneously. 484 In true moving bed (TMB) chromatography, the stationary phase moves in a counter-current direction to the solid phase.…”

Section: Basic Smb Principlesmentioning

confidence: 99%

“…487 The first recorded SMB chromatographic technique was developed in the petrochemical industry in the late 1940s 488 and has been widely used industrially in petrochemical refineries since the 1970s, in high-fructose corn-syrup processing since the 1980s, and enantiomer separations in the pharmaceutical industries since the 1990s. 484, 489 The concept of SMB technology relies on adjusting the bed transport rate in between the propagation velocity of the fast moving (weaker binding, 'cat') and slow moving (stronger binding, 'turtle') components (Fig. 13).…”

Section: Green Chemistry Tutorial Reviewmentioning

confidence: 99%

“…13). 489 It was designed to simulate the solid phase movement of the corresponding true moving bed (TMB) process, in which the fluid and solid phases flow counter-currently to each other. 490,491 It continuously separates or purifies feed streams using very much the same chromatography mechanisms, including adsorption, ion exchange, size exclusion, hydrophobic interactions, chiral interactions, affinity, or a combination of these mechanisms.…”

Section: Green Chemistry Tutorial Reviewmentioning

confidence: 99%

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Pre-treatment and extraction techniques for recovery of added value compounds from wastes throughout the agri-food chain

et al. 2016

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Section: Basic Smb Principlesmentioning

confidence: 99%

Section: Basic Smb Principlesmentioning

confidence: 99%

Section: Green Chemistry Tutorial Reviewmentioning

confidence: 99%

Section: Green Chemistry Tutorial Reviewmentioning

confidence: 99%

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Pre-treatment and extraction techniques for recovery of added value compounds from wastes throughout the agri-food chain

et al. 2016

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“…Simulated moving bed 3.1. Linear isotherm For SMB, the productivity and the dimensionless flow rates are defined as [2]: …”

Section: Problem Statementmentioning

confidence: 99%

Optimal performance of single-column chromatography and simulated moving bed processes for the separation of optical isomers

Medi

Kazi

Amanullah

2013

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. Chromatography has been established as the method of choice for the separation and purification of optically pure drugs which has a market size of about 250 billion USD. Single column chromatography (SCC) is commonly used in the development and testing phase of drug development while multi-column Simulated Moving Bed (SMB) chromatography is more suitable for large scale production due to its continuous nature. In this study, optimal performance of SCC and SMB processes for the separation of optical isomers under linear and overloaded separation conditions has been investigated. The performance indicators, namely productivity and desorbent requirement have been compared under geometric similarity for the separation of a mixture of guaifenesin, and Tröger's base enantiomers. SCC process has been analyzed under equilibrium assumption i.e., assuming infinite column efficiency, and zero dispersion, and its optimal performance parameters are compared with the optimal prediction of an SMB process by triangle theory. Simulation results obtained using actual experimental data indicate that SCC may compete with SMB in terms of productivity depending on the molecules to be separated. Besides, insights into the process performances in terms of degree of freedom and relationship between the optimal operating point and solubility limit of the optical isomers have been ascertained. This investigation enables appropriate selection of single or multi-column chromatographic processes based on column packing properties and isotherm parameters. IntroductionContinuous chromatographic separation is the method of choice for large-scale production due to its higher productivity and robustness [1; 2]. Simulated moving bed (SMB), introduced in 1960 [3], has become the bench mark in this regard. Backed by the celebrated triangle theory [4], it is possible to identify the region of complete separation and find a relation between decision variables and performance indicators in a relatively straightforward manner. On the other hand, singlecolumn chromatography (SCC) although does not appear to be competitive against SMB, it is still attractive due to higher flexibility, lower capital investment and quick analysis [5]. In this paper, under equilibrium theory assumptions, we present mathematical analysis of SMB and SCC under linear and nonlinear ranges of operation. For Langmuir isotherm, new analytical results are utilized for obtaining the triangular region of the SMB process [4] and elution profiles of the SCC process [6]. Thanks to equilibrium theory, it is possible to highlight optimal operating points and theoretical degrees of freedom for both processes without elaborate numerical methods and multi-objective optimization algorithms.

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Adsorption, Liquid Separation

Bergh

Smolders

Vos

2021

Kirk-Othmer Encyclopedia of Chemical Technology

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In industry, recovery and purification of the desired end product is a crucial step in the production of many chemicals, arguably as important as the synthesis itself. The cost of separation and purification often contributes a large part of the total production cost. Selection of the appropriate separation technique and optimization of the purification process are hence of critical importance. Adsorption has been used since history for the purification and separation of both gaseous and liquid streams. Sand filtration is known since ancient times and is one of the first examples of human water treatment. Even though the exact nature and mechanism of adsorption processes have long not been well understood, adsorption has been used for a huge variety of applications through all of human history. The separation of dyes, contaminant removal from water, decolorization of sugars, and recovery of fermented products are only a few examples. Nearly every modern‐day industrial chemical‐manufacturing process requires some form of separation in general and adsorption in specific. For instance, every catalytic reaction on a solid catalyst is characterized by an adsorption step, potentially rate determining. In this article, the basic fundamentals of adsorption, the different adsorbent types and process modes, and a selection of the most relevant industrial adsorptive separations are discussed.

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Simulated moving bed chromatography for the separation of enantiomers

Cited by 346 publications

References 134 publications

Pre-treatment and extraction techniques for recovery of added value compounds from wastes throughout the agri-food chain

Pre-treatment and extraction techniques for recovery of added value compounds from wastes throughout the agri-food chain

Optimal performance of single-column chromatography and simulated moving bed processes for the separation of optical isomers

Adsorption, Liquid Separation

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