Simulated cost‐effectiveness of a novel precision‐guided dosing strategy in adult patients with Crohn's disease initiating infliximab maintenance therapy
Elmar R. Alizadeh,
Thierry Dervieux,
Severine Vermeire
et al.
Abstract:BackgroundPatients with Crohn's disease (CD) who lose response to biologics experience reduced quality of life (QoL) and costly hospitalizations. Precision‐guided dosing (PGD) provides a comprehensive pharmacokinetic (PK) profile that allows for biologic dosing to be personalized. We analyzed the cost‐effectiveness of infliximab (IFX) PGD relative to two other dose intensification strategies (DIS).MethodsWe developed a hybrid (Markov and decision tree) model of patients with CD who had a clinical response to I… Show more
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