Simulated brain networks reflecting progression of Parkinson’s disease
Kyesam Jung,
Simon B. Eickhoff,
Julian Caspers
et al.
Abstract:Neurodegenerative progression of Parkinson's disease affects brain structure and function and, concomitantly, alters topological properties of brain networks. The network alteration accompanied with motor impairment and duration of the disease is not yet clearly demonstrated in the disease progression. In this study, we aim at resolving this problem with a modeling approach based on large-scale brain networks from cross-sectional MRI data. Optimizing whole-brain simulation models allows us to discover brain ne… Show more
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