“…Devine et al, 1996;Ginovart et al, 2002;Gregory et al, 2004a), and as essential inputs to the simulation of bacterial population biology and ecology (Kreft et al, 1998(Kreft et al, , 2001Ginovart et al, 2005;Prats et al 2006). COSMIC-Rules is based on the COSMIC (Gregory et al 2004a(Gregory et al , 2004b(Gregory et al , 2005Paton et al 2005) and RUBAM models, which were designed to create detailed simulations that were biologically accurate and computable within practical time frames (Gregory et al, 2006). However, where COSMIC had relatively simplistic yet explicit implementations of gene expression and evolution, COSMIC-Rules is rule-based with implicit implementations of gene expression that allow the compression of genetic information and facilitate more rapid computation.…”