Simulated Adreno-Cortical Activity During Pregnancy in an Addisonian Patient 1

Jailer, Joseph W.; Knowlton, Abbie I.

doi:10.1172/jci102381

Cited by 111 publications

(11 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The direction of the concentration gradient between cord and maternal plasma suggests that the plasma 17-ketosteroids of the newborn may be derived from some tissue in the fetal circulation other than from the mother, possibly from the internal cortex of the fetal adrenal or the placenta. It is relevant that several previous workers have observed a progressive increase during pregnancy of urinary 17-ketosteroid excretion in women with proven adrenocortical insufficiency, even though these women had essentially no urinary 17-ketosteroid excretion prior to pregnancy (11)(12)(13) 17-ketosteroids from 19 full-term, newborn infants, and from 20 premature infants. The premature infants had attained weights ranging from 793 to-2381 grams when the samples were taken.…”

Section: Studies On Full-term Newbornsmentioning

confidence: 97%

Plasma 17-Ketosteroids of Full-Term and Premature Infants12

Gardner¹,

Walton²

1954

J. Clin. Invest.

View full text Add to dashboard Cite

The adrenal cortex of the newborn exhibits a relative lack of responsiveness to the administration of adrenocorticotrophic hormone which has been the subject of several investigations and is adequately reviewed elsewhere (1). These observations, together with the presence of the fetal reticular zone of the adrenal cortex and the recent report of very low concentrations of compound F-like substances in newborn plasma (2), are all reminiscent of the findings in infants and children with congenital adrenal hyperplasia (3,4).Since children with congenital adrenal hyperplasia have been shown to have markedly elevated concentrations of plasma neutral 17-ketosteroids (5), it was thought desirable to investigate the concentrations of these steroids in the plasma of newborn infants. The purpose of this paper is to describe analytic data obtained when plasma samples from a group of normal full-term infants and a group of premature infants were analyzed for neutral 17-ketosteroids. METHODS

show abstract

Section: Studies On Full-term Newbornsmentioning

confidence: 97%

Plasma 17-Ketosteroids of Full-Term and Premature Infants12

Gardner¹,

Walton²

1954

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…However, the source of these "adrenal-like" steroids has not been clearly established. It is also known that urinary steroid values in patients with Addison's disease show progressive increases with advancing pregnancy (23,24). Again, the source of these "corticoids" remains a matter of debate.…”

Section: Hypopituitarismmentioning

confidence: 99%

“…(Submitted for publication January 26, 1955; accepted February 23,1955) The response of the adrenal cortex to exogenous ACTH has been recognized as one of the more specific and quantitative tests of adrenal function (1). Changes in the 24-hour excretion values of urinary 17-ketosteroids and 17-hydroxycorticosteroids during ACTH administration have proved to be valuable indices of adrenocortical capacity (2,3).…”

mentioning

confidence: 99%

The Effect of Intravenously-Administered ACTH on Plasma 17, 21-Dihydroxy-20-Ketosteroids in Normal Individuals and in Patients with Disorders of the Adrenal Cortex1

Christy¹,

Wallace²,

Jailer³

1955

J. Clin. Invest.

Self Cite

104

View full text Add to dashboard Cite

Studies have been performed in this laboratory on plasma 17-hydroxycorticosteroid levels in patients with endocrine and non-endocrine diseases (12). During the course of these investigations, it became apparent that there are disease states, particularly primary adrenal insufficiency and hypopituitarism, in which plasma 17-hydroxycorticosteroid levels determined before and after ACTH administration may give a more accurate picture of adrenal capacity than single plasma 17-hydroxycorticosteroid levels. These findings prompted an evaluation of plasma 17-hydroxycorticosteroid response to ACTH in patients with a variety of disorders of the adrenal cortex as compared with normal subjects.

show abstract

“…Normal human pregnancy is associated with maternal adrenocortical hyperfunction that apparently is secondary to increased corticotropin (ACTH) secretion, since concentrations of maternal plasma ACTH increase progressively during pregnancy; urinary excretion of free cortisol is relatively resistant to glucocorticoid negative-feedback suppression (1,2). It has been suggested that the placenta is involved in this increased secretion of ACTH because several workers have reported the presence of bioactive (1)(2)(3)(4)(5)(6)(7)(8) or immunoreactive ACTH (1)(2)(3) in placental extracts.…”

mentioning

confidence: 99%

Human placental immunoreactive corticotropin, lipotropin, and beta-endorphin: evidence for a common precursor.

Odagiri¹,

Sherrell²,

Mount³

et al. 1979

Proc. Natl. Acad. Sci. U.S.A.

102

View full text Add to dashboard Cite

The Normal human pregnancy is associated with maternal adrenocortical hyperfunction that apparently is secondary to increased corticotropin (ACTH) secretion, since concentrations of maternal plasma ACTH increase progressively during pregnancy; urinary excretion of free cortisol is relatively resistant to glucocorticoid negative-feedback suppression (1, 2). It has been suggested that the placenta is involved in this increased secretion of ACTH because several workers have reported the presence of bioactive (1-8) or immunoreactive ACTH (1-3) in placental extracts. The ACTH extracted from placenta appears to consist, in addition to ACTH, of a high Mr form of the hormone (3). In mouse pituitary tumor cells (9, 10) and human nonpituitary carcinoma cells (11,12), ACTH appears to be formed by processing of a high Mr precursor molecule. This ACTH precursor contains the 13-lipotropin (f3LPH) sequence and, therefore, may also be processed to form f3LPH and its related peptides, yLPH [(1-58)/3LPH] and f3-endorphin [BEND,/3LPH] (9,11,12). The high Mr ACTH precursor molecule thus contains antigenic determinants for ACTH, the LPHs, and BEND.In the present study, we have used radioimmunoassays for ACTH, LPH (J3LPH plus "yLPH), 'yLPH, and fiEND, gel exclusion chromatography, affinity chromatography, sodium

show abstract

Simulated Adreno-Cortical Activity During Pregnancy in an Addisonian Patient 1

Cited by 111 publications

References 6 publications

Plasma 17-Ketosteroids of Full-Term and Premature Infants12

Plasma 17-Ketosteroids of Full-Term and Premature Infants12

The Effect of Intravenously-Administered ACTH on Plasma 17, 21-Dihydroxy-20-Ketosteroids in Normal Individuals and in Patients with Disorders of the Adrenal Cortex1

Human placental immunoreactive corticotropin, lipotropin, and beta-endorphin: evidence for a common precursor.

Contact Info

Product

Resources

About