The objective of this research is to develop a pavement design procedure that allows calibrating the design variables of asphalt pavements using regionalized conditions, to obtain efficient pavement performance for developing countries with limited resources and data. This study analyzes the roads of the state of Baja California, Mexico; where type structures are determined and the performance grade of the binder used in the manufacture of asphalt concrete is regionalized according to the weather conditions altitude, traffic, and quality of the available materials. In a complementary way, the economic incidence of pavements during its service life is analyzed, projecting the analysis with different pavement structures and damage coefficients. The results show that this approach favors the asphalt pavements that comply with the projected in its service life, reducing maintenance interventions and costs.