Simplify your approach to the diagnosis and treatment of PCOS

Discovery and validation of peritoneal endometriosis biomarkers in peritoneal fluid and serum

“…Endometriosis is represented by three main subphenotypes: ovarian endometriosis (OE), superficial peritoneal endometriosis (PE) and deep infiltrating endometriosis (DIE) (5). To diagnose endometriosis, transvaginal ultrasonography can be used to detect OE and DIE (6,7), with pelvic magnetic resonance imaging to assess the extent of DIE (1). However, the detection of PE, characterized by superficial endometrial lesions occurring on the peritoneum, remains challenging (8)(9)(10)(11).…”

“…Indeed, accuracy of diagnosis is dependent on practitioners' laparoscopic skills due to the diversity of endometriotic appearances and locations, insofar that endometriosis may be inadvertently missed with less obvious or microscopic endometriotic lesions (14). Consequently, there is often a delay with an average of eight years in the diagnosis of endometriosis (6). Thus, there is a great need to identify a less invasive method for PE diagnosis, which would have a groundbreaking impact in preventing or delaying disease progression, improving patients' quality of life and the efficacy of available treatments.…”