Simplified sperm retrieval and intracytoplasmic sperm injection in patients with azoospermia

Tsirigotis, M.; Pelekanos, M.; Yazdani, Nahid; Boulos, A.; Foster, Claire; Craft, Ian

doi:10.1111/j.1464-410x.1995.tb00771.x

Cited by 27 publications

(13 citation statements)

References 18 publications

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“…When making a decision as to what to do, one must also take into account that epididymovasostomy carried out in the most effi cient manner, by microsurgery, is a difficult procedure requiring considerable microsurgical skill, and the out come of successful fertility, as in this small series, is not good [14,15]. The situation has altered, however, in the last year or so, with the introduction of direct sperm aspi ration from the epididymis or testis and intracytoplasmic sperm injection (ICSI) into the ovum, with successful out come in many cases [16]. Fertilisation is therefore achiev able in patients in whom vasovasostomy has failed, and the alternatives should be fully discussed with the patient before proceeding with a second attempt.…”

Section: Discussionmentioning

confidence: 98%

Failed Vasectomy Reversal: Is a Further Attempt Worthwhile Using Microsurgery?

Fox

1997

Eur Urol

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Section: Discussionmentioning

confidence: 98%

Failed Vasectomy Reversal: Is a Further Attempt Worthwhile Using Microsurgery?

Fox

1997

Eur Urol

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“…IN THE TREATMENT of severe oligozoospermia or azoospermia, a number of techniques including microsurgical epididymal sperm aspiration (MESA) 7,8 or percutaneous epididymal sperm aspiration (PESA) 8,9 have been used. It is the advantage of TESE compared with such procedures to provide a histological evaluation of the testicular biopsy in parallel with it 10 …”

Section: Discussionmentioning

confidence: 99%

Testicular sperm extraction with intracytoplasmic sperm injection for male infertility

Igarashi

Suzuki

Ichikawa

et al. 2003

Reprod Medicine & Biology

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Testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI) is an effective procedure for the treatment of male infertility, obstructive and non-obstructive azoospermia. We have reviewed our experience to investigate the correlation of TESE-ICSI with morphological, biophysical and endocrine profiles in 27 men. Testicular spermatozoa could be retrieved in 25 of 27 patients who underwent TESE. In two cases, testicular spermatozoa could not be recovered and their serum follicle-stimulating hormone (FSH) levels were significantly higher than those of the former group. However, spermatozoa could be retrieved in sufficient numbers for ICSI, even in the patient with the highest FSH concentration. Johnsen scores evaluated by diagnostic pre-TESE open biopsies were significantly higher in the cases with viable testicular spermatozoa than those in the cases without spermatozoa. However, even in the patient whose Johnsen score was 2.1, testicular spermatozoa could be retrieved with TESE, and pregnancy was achieved by ICSI. The serum FSH levels and the histological findings of the testes were strong predictors for successful TESE and provided useful information for consultation and making treatment decisions on an individual case. However, whether a patient has enough spermatozoa so that an IVF procedure with ICSI is possible can only be answered by a trial TESE. (Reprod Med Biol 2003; : 31-35).

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“…MESA requires certain surgical skills; its cost is relatively high; it requires general anesthesia, and there is a [5,6]. Fertilization rates of oocytes obtained by aspiration for IVF are approximately 80-90% [7].…”

Section: Discussionmentioning

confidence: 99%

Percutaneous Testicular Sperm Aspiration and Intracytoplasmic Sperm Injection in Obstructive and Non-Obstructive Azoospermia: An Easy Alternative to TESE and MESA

2002

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Objective: To evaluate the recovery rate of sperm from the testis using percutaneous testicular aspiration with a 22-gauge hypodermic needle followed by evaluation of the fertilization rate and pregnancy rate after intracytoplasmic sperm injection. Materials and Methods: This is a prospective observational study performed in a private in vitro fertilization setting in Kuwait. Fifteen patients with obstructive and non-obstructive azoospermia were included in the study. Thirteen of them had previous microepididymal sperm aspiration, percutaneous epididymal sperm aspiration or testicular sperm extraction. The sperm were retrieved using percutaneous testicular aspiration under local analgesia. This was followed by intracytoplasmic sperm injection. A total of 146 eggs were collected and 112 were injected. Results: Normal fertilization occurred in 91 oocytes (87.5%) and the total number of embryos cleaved was 83 (91%). Embryo transfer was performed in 13 with pregnancy rate of 33.3 per treatment cycle and 38.5 per embryo transfer. Failure to retrieve sperm was encountered in 2 cases both in the hypospermatogenesis group. Conclusions: Percutaneous testicular sperm aspiration using hypodermic needles under local analgesic is an easy and cheap method with high patient acceptability, minimal complications and no need of special training. In this small group, it seems to have an acceptable success rate in terms of sperm retrieval and pregnancy in the obstructive type as well as hypospermatogenesis, but to lesser extent.

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Simplified sperm retrieval and intracytoplasmic sperm injection in patients with azoospermia

Abstract: This extensive series of PESA/ICSI cycles indicates that PESA can be used successfully to retrieve spermatozoa in patients with azoospermia. The technique is simple, cost-effective and is associated with fewer complications compared to an open microsurgical procedure.

Cited by 27 publications

References 18 publications

Failed Vasectomy Reversal: Is a Further Attempt Worthwhile Using Microsurgery?

Failed Vasectomy Reversal: Is a Further Attempt Worthwhile Using Microsurgery?

Testicular sperm extraction with intracytoplasmic sperm injection for male infertility

Percutaneous Testicular Sperm Aspiration and Intracytoplasmic Sperm Injection in Obstructive and Non-Obstructive Azoospermia: An Easy Alternative to TESE and MESA

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