Simplified procedure for forming polymer-based ion-selective electrodes

Fogt, Eric J.; Cahalan, Patrick T.; Jevne, Allan.; Schwinghammer, Michelle A.

doi:10.1021/ac00283a044

Cited by 16 publications

(7 citation statements)

References 16 publications

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“…In recent years, we have attempted to develop a new class of ion-selective membranes employing a highly adhesive one-component room temperature vulcanizing-type silicone rubber (RTV-1-type SR) matrix for all-solid-state ion sensors − unlike PVC, SR-based membranes may be formulated without plasticizer (owing to their low glass transition temperature), adhere strongly to most solid surfaces, and exhibit less interference from lipophilic anions present in biological fluids. However, the application of SR-based membranes to all-solid-state ion sensors has not been so popular, due in part to their high electrical resistance, the cause of slow response and noisy signal. , Furthermore, most electroactive compounds are not compatible with the SR matrix, and the resultant membranes exhibit either irreproducible or negligible potentiometric responses: only a few neutral carriers, such as valinomycin, certain calix[4]arene derivatives, and nonactin, are known to exhibit the same degree of ion carrying ability in the SR matrix as in the highly plasticized PVC matrix. ,− These problems prompted us to consider the use of an appropriate plasticizer and lipophilic salts for the SR matrix in order to lower its electrical resistance and to help uniform dissolution of electroactive components in the resulting membrane…”

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confidence: 99%

One-Component Room Temperature Vulcanizing-Type Silicone Rubber-Based Calcium-Selective Electrodes

Kim

Lee

et al. 1996

Anal. Chem.

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New calcium-selective membranes for all-solid-state ion sensors are developed with a highly adhesive one-component room temperature vulcanizing-type silicone rubber (RTV-1-type SR) matrix. The membranes are formulated with 21.6 wt % bis(2-ethylhexyl) adipate, 0.3 wt % tetradodecylammonium tetrakis(p-chlorophenyl)borate (ETH 500), 0.1 wt % potassium tetrakis(p-chlorophenyl)borate, and 0.8 wt % calcium-selective neutral carrier ETH 129 or ETH 1001. Plasticizer added to the RTV-1-type SR matrix not only decreases the bulk membrane resistance but also increases the solubility of electroactive components incorporated in the membrane without significantly deteriorating its adhesive strength. It is found that the lipophilic salt ETH 500 remarkably enhances the calcium selectivity of ETH 129 or ETH 1001 ligands in the SR matrix; the selectivity coefficients ([Formula: see text] by separate solution method, where j = Li(+), Na(+), K(+), or Mg(2+)) for the optimized membranes were below 10(-5). Potentiometric characteristics of planar-type Ag electrodes coated with optimized RTV-1-type SR membranes, e.g., response slope 29.0 ± 0.5 mV/decade, detection limit below 5.0 × 10(-7) M a(Ca)((2+)), and 2-3 mV of potential drift per day, were virtually the same as those of the corresponding poly(vinyl chloride) membrane-based conventional electrodes, but with greatly enhanced sensor-to-sensor reproducibility and lifetime (3-9 weeks).

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confidence: 99%

One-Component Room Temperature Vulcanizing-Type Silicone Rubber-Based Calcium-Selective Electrodes

Kim

Lee

et al. 1996

Anal. Chem.

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“…In the second step the electrochemical selectivity is introduced by locally doping this blank membrane with the electroactive ingredients. The idea of creating ion-selective membranes by doping a standard plasticized PVC tubing has been used previously (9). Despite the fact that the composition of the membranes and of the swelling solutions has not been optimized, those membranes have shown a respectable sensitivity.…”

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confidence: 99%

Multisensing ion-selective field effect transistors prepared by ionophore doping technique

Bezegh¹,

Bezegh²,

Janata³

et al. 1987

Anal. Chem.

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“…Among various polymers tested, poly(vinyl chloride) (PVC) shows the best performance due to the appropriate physical/mechanical properties with good solubility of the plasticizer [174]. The signals come from the transmembrane potentials that are related to the analyte concentration.…”

Section: Permeability and Permselectivitymentioning

confidence: 99%

Implantable Electrochemical Sensors for Biomedical and Clinical Applications: Progress, Problems, and Future Possibilities.

Dong²,

Cao³

et al. 2007

CMC

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Biosensors are of great interest for their ability to monitor clinically important analytes such as blood gases, electrolytes, and metabolites. A classic example is to monitor the dynamics of blood-glucose levels for treating diabetes. However, the current practice, based on a three decade old technology, requires a drop of blood on a test strip, which is in dire need of replacement. The increasing demands and interests in developing implantable glucose sensors for treating diabetes has led to notable progress in this area, and various electrochemical sensors have been developed for intravascular and subcutaneous applications. However, implantations are plagued by biofouling, tissue destruction and infection around the implanted sensors and the response signals must be interpreted in terms of blood or plasma concentrations for clinical utility, rather than tissue fluid levels. This review focuses on the potentials and pitfalls of implantable electrochemical sensors and presents our opinions about future possibilities of such implantable devices with respect to biocompatibility issues, long-term calibration, and other aging effects on the sensors.

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Simplified procedure for forming polymer-based ion-selective electrodes

Cited by 16 publications

References 16 publications

One-Component Room Temperature Vulcanizing-Type Silicone Rubber-Based Calcium-Selective Electrodes

One-Component Room Temperature Vulcanizing-Type Silicone Rubber-Based Calcium-Selective Electrodes

Multisensing ion-selective field effect transistors prepared by ionophore doping technique

Implantable Electrochemical Sensors for Biomedical and Clinical Applications: Progress, Problems, and Future Possibilities.

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