Simplified assessment of arterial graft patency using indium-labelled-platelet scintigraphy

St, Zwas; Walden, Raphael; Elkanovitz, R; Bochurowski, S; Bass, A

doi:10.1097/00006231-198709000-00004

Cited by 3 publications

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“…4 Finally, using a qualitative assessment, no radioactivity suggesting platelet activity was noted in two ePTFE femoropopliteal grafts at either anastomosis 10 months aft~, surgery. 39 It is clear that, regarding platelet activity, there are many theoretical short-term advantages to ePTFE grafts over Dacron grafts that have been documented in the laboratory setting. In addition, ePTFE appears to be a less platelet-reactive graft early after implantation in humans.…”

Section: Discussionmentioning

confidence: 99%

Platelet reactivity in human aortic grafts: A prospective, randomized midterm study of platelet adherence and release products in Dacron and polytetrafluoroethylene conduits

Wakefield

Shulkin

Fellows

et al. 1989

Journal of Vascular Surgery

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Platelet-related phenomena at the blood-surface interface of randomly placed knitted Dacron (n = 6) and polytetrafluoroethylene (ePTFE) (n = 6) interposition aortic grafts were studied in patients undergoing abdominal aortic aneurysmectomy. Luminal accumulation of platelets was assessed by infusing indinm-lll-oxine (400 ~Ci) labeled autologous platelets and imaging grafts at 1 week, 3 months, and 6 months after surgery. Image analysis included an indium ratio technique (comparing aortic graft radioactivity to that of an lilac artery) and a red blood cell technetium subtraction technique (excluding blood pool radioactivity from graft radioactivity, with the heart or iliac artery serving as reference regions). Plasma levels of [3-thromboglobulin and platelet factor 4 were correlated with platelet accumulations on the aortic prostheses. Differences in graft radioactivity or platelet-release products were not evident 1 week after surgery. Three months after implantation, Dacron and ePTFE conduits exhibited 87% and 47% (p < 0.05) more radioactivity with the indium ratio technique than the iliac artery. Similary, increased Dacron compared with ePTFE graft radioactivity was noted using technetium subtraction techniques: 71% vs 30% with a heart reference and 26% vs 11% with an iliac artery reference, respectively. Increases in graft radioactivity correlated with increases in both plasma I~-thromboglobulin and platelet factor 4 at 3 months (r = 0.6 to 0.9; p < 0.05 to 0.001 depending on the imaging technique used). At 6 months, differences did not persist. In fact, technetium subtraction techniques suggested less Dacron conduit reactivity. It is speculated that differences in platelet accumulation and activation associated with different graft substrates may prove clinically important.

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Section: Discussionmentioning

confidence: 99%

Platelet reactivity in human aortic grafts: A prospective, randomized midterm study of platelet adherence and release products in Dacron and polytetrafluoroethylene conduits

Wakefield

Shulkin

Fellows

et al. 1989

Journal of Vascular Surgery

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Indium-111 platelet scintigraphy in vascular disease

Smyth

Dodd

Walker

1995

Journal of British Surgery

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Indium-111 labelled platelet scintigraphy permits simple, accurate evaluation of platelet kinetics and sites of deposition. The most meaningful results are obtained from serial scans, although these are clinically useful in only a few of the many applications that have been suggested, principally in studies of acute thrombosis, prosthetic graft thrombogenicity and antiplatelet medication. Key pitfalls are associated with selection of regions and patient variation.

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The Effects of New Platelet Inhibitory Drug E-5510 on Platelet Deposition on Aortic Bifurcation Grafts: Assessment by Indium-111-Oxime Labeled Platelet Imaging

Suga¹,

Nishigauchi²,

Kume³

et al. 1998

Clinical Nuclear Medicine

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The effects of a recently synthesized anti-platelet aggregation drug (E-5510) on platelet deposition in a knitted Dacron aortic graft underwent preliminary evaluation by In-111 oxime labeled platelet imaging. Seven patients undergoing aortofemoral bypass using this graft for occlusive disease were randomized into two groups: those receiving E-5510 and those receiving no medication. This agent was administered for 17 days postoperatively, and on the 14th day In-111 platelets were injected and images were acquired at 24, 48, and 72 hours. Platelet deposits in the grafts were assessed by the ratios of graft radioactivity to that of the adjacent native iliac arteries. Platelet deposition at the sites of anastomosis and deposition along the entire graft were normalized by initial deposition at 24 hours, and had significantly decreased at 72 hours in the three treated patients, while the normalized deposition increased progressively over time in the remaining four nonmedicated patients. E-5510 seems to have the potential to inhibit excessive platelet deposition on recently implanted grafts.

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Simplified assessment of arterial graft patency using indium-labelled-platelet scintigraphy

Cited by 3 publications

References 0 publications

Platelet reactivity in human aortic grafts: A prospective, randomized midterm study of platelet adherence and release products in Dacron and polytetrafluoroethylene conduits

Platelet reactivity in human aortic grafts: A prospective, randomized midterm study of platelet adherence and release products in Dacron and polytetrafluoroethylene conduits

Indium-111 platelet scintigraphy in vascular disease

The Effects of New Platelet Inhibitory Drug E-5510 on Platelet Deposition on Aortic Bifurcation Grafts: Assessment by Indium-111-Oxime Labeled Platelet Imaging

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