Abstract. A flow-injection spectrophotometric method is developed for determination of N-acetyl-Lcysteine (NAC) in pharmaceutical formulations. The method is based on coupled redox-complexation reaction, the first step of which is the reduction of Fe III by NAC; the second one includes the complexation of Fe . The analytical frequency was 60 h -1 . Usual excipients used as additives in pharmaceuticals do not interfere with the analysis of NAC. The proposed method is simple, rapid, sensitive, accurate and precise (repeatability RSD 0.29 %, n = 10), and can be applied for determination of NAC in pharmaceutical formulations up to nanomole quantity. (doi: 10.5562/cca1753)