Simple synthesis route for fabrication of protective photo‐crosslinked poly(zwitterionic) membranes for application in non‐enzymatic glucose sensing

Abstract

This work focuses on the fabrication of non-enzymatic glucose sensing materials based on laser-formed Au nanoparticles embedded in Ti-textured substrates. Those materials possess good catalytic activity toward glucose oxidation in 0.1 Â phosphate buffered saline as well as resistance to some interferants, such as ascorbic acid, urea, and glycine. The electrodes are further coated with three different polymers, that is, Nafion, photo-crosslinked poly(zwitterions) based on sulfobetaine methacrylate, and a hybrid membrane consisting of both polymers. Both the optimal integrity of the material and its catalytic activity toward glucose oxidation were maintained by the hybrid membranes with a large excess of poly(zwitterions) (mass ratio 20:1). The chemical structures of the as-formed membranes are confirmed by Fourier transform infrared spectroscopy. Due to the zwitterionic nature of the coating, the electrodes are resistant to biofouling and maintain electrochemical activity toward glucose for 4 days.Moreover, due to the synergistic effect of both Nafion and poly(zwitterions), the interference from the two compounds, namely, from acetylsalicylic acid and acetaminophen, was diminished. Besides the presence of polymer membranes, the electrode possesses a sensitivity of 36.8 μA cm À2 mM À1 in the linear range of 0.4-12 mM, while the limit of detection was estimated to be 23 μM. Finally, the electrodes are stable, and their response is not altered even by 1,000 bending cycles.

Tailoring Diffusional Fields in Zwitterion/Dopamine Copolymer Electropolymerized at Carbon Nanowalls for Sensitive Recognition of Neurotransmitters

“…A similar set of bands, although slightly shifted, was observed in our previous work in a hybrid Nafion-co−PZ coating for glucose sensing applications. 50 These bands are also visible on the sample of the pristine PZ coating (Figure S1). Generally, there are no substantial differences in the whole range of the spectrum except the C−H bond region (inset).…”

“…Those fingerprint bands occur only in the hybrid coating and therefore should come only from zwitterionic components of the coating. A similar set of bands, although slightly shifted, was observed in our previous work in a hybrid Nafion-co–PZ coating for glucose sensing applications …”

Zwitterionic Polymers Coating Antibiofouling Photoelectrochemical Aptasensor for In Vivo Antibiotic Metabolism Monitoring and Tracking

“…Furthermore, except for the XPS measurements, Fourier transform infrared (FT-IR) spectra of TiO 2 NTs/PDA and TiO 2 NTs/PDA/SBMA were presented in Figure e. After SBMA was grafted, two featured peaks at 1160 and 1030 cm –1 were observed, which can be identified as asymmetric and symmetric stretching vibrations of SO bonds in SBMA . According to the above XPS and FTIR analysis, the combination of SBMA on TiO 2 NTs/PDA has been successfully verified.…”