Abstract:A convenient and facile approach to functionalized 4-substituted 3,5-dihydroxy-5-(trichloromethyl)furan-2(5H)-ones was developed. This method is based on regioselective synthesis of novel furan-2,3-diones containing the trichloromethyl group and subsequent hydrolysis. The structures of compounds were unambiguously confirmed by single-crystal X-ray diffraction.
As a result of the reaction of 5-substituted 4-trichloroacetylfuran-2,3-diones with aromatic amines, 4-substituted 5-hydroxy 5-(trichloromethyl)dihydrofuran-2,3-diones, were synthesized, which have antibacterial and antinociceptive activities.
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