Simple purification of recovered [18O]H2O by UV, ozone, and solid-phase extraction methods

Moon, Woo Yeon; Oh, Seung Jun; Cheon, Jun; Chae, Won Seok; Lim, Sung Jae; Cho, Si Man; Moon, Dae Hyuk

doi:10.1016/j.apradiso.2006.06.010

Cited by 7 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chloride (0.895 g L À 1 ), sodium (1.945 g L À 1 ) and potassium ions (1.811 g L À 1 ) contributed 24.7 mg to the total weight of the water in the pycnometer (V¼5.304 mL) resulting in a difference in density of 0.005 g mL À 1 . This corresponds to a difference of 2.5% in 18 O enrichment ( (Asti et al, 2007;Moon et al, 2007) as it was similarly observed at the begin of our study.…”

Section: Characterisation Of Recycled [ 18 O]h 2 O After Low Temperatsupporting

confidence: 78%

“…The degradation of acetonitrile was much slower than previously described (Moon et al, 2007). An elimination of acetonitrile within 24 h was reported.…”

Section: Reference Study With Contaminated [ 16 O]h 2 Omentioning

confidence: 73%

“…2 and the conditions described in Section 2.5. allowed a rather complete separation of [ 18 O]water from contaminants even from salts. Other authors (Asti et al, 2007;Moon et al, 2007) also determined the concentration of ions before and after the recycling process. A direct comparison to our work was difficult because in both studies, the concentrations of ions were in the low mg L À 1 range before the distillation.…”

Section: Characterisation Of Recycled [ 18 O]h 2 O After Low Temperatmentioning

confidence: 99%

“…To evaluate the reactivity of the [ 18 F]F -produced with recycled [ 18 O]water, the standardised synthesis of [ 18 F]FDG is usually performed (Asti et al, 2007;Moon et al, 2007;Nishijima et al, 2002). In our study we applied the sensitive radiosynthesis of [ 18 F]fluspidine for that purpose.…”

Section: Use Of [ 18 F]f à In Labelling Reactionsmentioning

confidence: 99%

See 3 more Smart Citations

Convenient recycling and reuse of bombarded [ 18 O]H 2 O for the production and the application of [ 18 F]F −

Rötering

Franke

Zessin

et al. 2015

Applied Radiation and Isotopes

View full text Add to dashboard Cite

Section: Characterisation Of Recycled [ 18 O]h 2 O After Low Temperatsupporting

confidence: 78%

“…The degradation of acetonitrile was much slower than previously described (Moon et al, 2007). An elimination of acetonitrile within 24 h was reported.…”

Section: Reference Study With Contaminated [ 16 O]h 2 Omentioning

confidence: 73%

Section: Characterisation Of Recycled [ 18 O]h 2 O After Low Temperatmentioning

confidence: 99%

Section: Use Of [ 18 F]f à In Labelling Reactionsmentioning

confidence: 99%

See 2 more Smart Citations

Convenient recycling and reuse of bombarded [ 18 O]H 2 O for the production and the application of [ 18 F]F −

Rötering

Franke

Zessin

et al. 2015

Applied Radiation and Isotopes

View full text Add to dashboard Cite

“…The reactions between [ 18 F]-fluoride and different substrates permit the synthesis of many PET radiopharmaceuticals and, in particular, of [ 18 F]-FDG (2-deoxy-2-[ 18 F]-fluoro-D-glucose), a most important radiotracer for oncological applications. The high cost of virgin enriched water has stimulated research into methods to re-use it [3][4][5][6][7]. Numerous studies have suggested that ionic contaminants originating from the [ 18 O] water target affect the [ 18 F] fluoride chemistry, resulting in low and variable radiofluorination yields [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Comparison between Different Techniques in Purification of 18O Enriched Water after Cyclotron Irradiation

Masoud

El-Kholany

Shahat

2018

The International Conference on Chemical and Environmental Engi

View full text Add to dashboard Cite

In the synthesis of 18 F-FDG by nucleophilic substitution method, 18 O-H 2 O is usually used as target water. The high cost of virgin 18 O-H 2 O enriched water pointed to recycle process after the first irradiation for the production of radiopharmaceuticals. The irradiated 18 O-H 2 O was contaminated by both organic substances (ethanol, acetonitrile, etc.) and inorganic ions (Cd 2+, Na + , K + , Cl -, etc). In our study different techniques (ozonolysis, UV, distillation and resin) were used to minimize the concentration of both organic substances and inorganic ions and evaluate the effectiveness of resin as method for the purification. The concentration of the TOC was decreased from 705 (mg/L) for the irradiated 18 O water to 12.36 (mg/L) and 4.8 (mg/L) by using UV and ozonolysis respectively. While the concentration of metal ions decreased and the conductivity decreased from 487 µ Si/cm for the irradiated 18 O water to 51.9 µ Si/cm when regenerated resin was used and to 20.8 µ Si/cm by distillation.

show abstract

Purification by ozonolysis of 18O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose)

Asti

Grassi

Sghedoni

et al. 2007

Applied Radiation and Isotopes

View full text Add to dashboard Cite

Simple purification of recovered [18O]H2O by UV, ozone, and solid-phase extraction methods

Cited by 7 publications

References 11 publications

Convenient recycling and reuse of bombarded [ 18 O]H 2 O for the production and the application of [ 18 F]F −

Convenient recycling and reuse of bombarded [ 18 O]H 2 O for the production and the application of [ 18 F]F −

Comparison between Different Techniques in Purification of 18O Enriched Water after Cyclotron Irradiation

Purification by ozonolysis of 18O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose)

Contact Info

Product

Resources

About