Simple phonic tic in multiple sclerosis

Lana-Peixoto, M. A.; Teixeira, Antônio Lúcio

doi:10.1191/1352458502ms829oa

Cited by 14 publications

(7 citation statements)

References 9 publications

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“…We have shown, however, that an isolated simple phonic tic could be a consequence of subcortical stroke involving the basal ganglia, specifically the caudate nucleus. In the literature there is a case report of an isolated simple phonic tic related to multiple sclerosis 8…”

Section: Discussionmentioning

confidence: 99%

Adult onset simple phonic tic after caudate stroke

et al. 2008

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We describe a case of adult onset simple phonic tic after subcortical stroke involving left caudate nucleus. In the acute phase of stroke the patient presented a mild right clumsiness with complete recovery one week after onset. Within 3 weeks after stroke the patient noticed the gradual onset of involuntary simple phonic tic consisting of an "a" sound which persists. The patient did not present motor tics or the typical Tourette syndrome co-morbidities, such as attention deficit or obsessive-compulsive disorder.

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Section: Discussionmentioning

confidence: 99%

Adult onset simple phonic tic after caudate stroke

et al. 2008

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“…Defined tic disorders in association with MS are extremely rare, which is somewhat surprising in view of the frequent finding of demyelinating lesions in basal ganglia and thalamus. 17 The patient reported in this submission showed onset of utterances at ~36 years of age that progressed to coprolalia and echolalia, in addition to paroxysmal dystonia. She had no known childhood history of tics, obsessive-compulsive symptoms, or abnormal movements related to basal ganglia dysfunction.…”

Section: Basal Ganglia Involvement In Multiple Sclerosismentioning

confidence: 81%

“…Although basal ganglia-related movement disorders in general appear infrequently in association with MS, paroxysmal dystonia is the most commonly reported one. 17 Our patient described paroxysmal contractions of her skeletal muscles that would result in a freezing of her posture lasting for a period of seconds; this occurs unex-pectedly while walking. A case of simple phonic tic, throat-clearing sounds with no premonitory symptoms, as the sole manifestation of basal ganglia dysfunction was reported in a 34-year-old woman with progressive MS, showing demyelinating lesions of the thalamus and basal ganglia.…”

Section: Basal Ganglia Involvement In Multiple Sclerosismentioning

confidence: 87%

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Current Status of Cannabis Treatment of Multiple Sclerosis with an Illustrative Case Presentation of a Patient with MS, Complex Vocal Tics, Paroxysmal Dystonia, and Marijuana Dependence Treated with Dronabinol

Deutsch¹,

Rosse²,

Connor³

et al. 2008

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Pain, spasticity, tremor, spasms, poor sleep quality, and bladder and bowel dysfunction, among other symptoms, contribute significantly to the disability and impaired quality of life of many patients with multiple sclerosis (MS). Motor symptoms referable to the basal ganglia, especially paroxysmal dystonia, occur rarely and contribute to the experience of distress. A substantial percentage of patients with MS report subjective benefit from what is often illicit abuse of extracts of the Cannabis sativa plant; the main cannabinoids include delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol. Clinical trials of cannabis plant extracts and synthetic Δ9-THC provide support for therapeutic benefit on at least some patient self-report measures. An illustrative case is presented of a 52-year-old woman with MS, paroxysmal dystonia, complex vocal tics, and marijuana dependence. The patient was started on an empirical trial of dronabinol, an encapsulated form of synthetic Δ9-THC that is usually prescribed as an adjunctive medication for patients undergoing cancer chemotherapy. The patient reported a dramatic reduction of craving and illicit use; she did not experience the “high” on the prescribed medication. She also reported an improvement in the quality of her sleep with diminished awakenings during the night, decreased vocalizations, and the tension associated with their emission, decreased anxiety and a decreased frequency of paroxysmal dystonia.

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“…[4] Extrapyramidal movement disorders have hardly been reported,[5] and there is only one published case report of phonic tics as a manifestation of Multiple Sclerosis in a 34-year-old lady, and motor tics have never been reported as a presenting feature. [6] While Acute Demyelinating Encephalomyelitis (ADEM) can present with tics, our case did not have encephalopathic features and the typical MRI findings seen in ADEM. [7] Our case highlights a very rare manifestation of demyelination, and underscores the importance of neuroimaging in the evaluation of acute-onset movement disorders including tics in children.…”

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confidence: 93%