Simple pharmacological test battery to assess efficacy and side effect profile of centrally acting muscle relaxant drugs

Farkas, Sándor; Berzsenyi, Pál; Kárpáti, E; Kocsis, Pál; Tarnawa, Istvàn

doi:10.1016/j.vascn.2004.11.005

Cited by 37 publications

(26 citation statements)

References 27 publications

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“…Abnormalities identified at high doses of tramadol and tapentadol in the FBC model were further ascertained and compared with oxycodone and morphine by the rota-rod test, because this test is a major tool to quantify the effects of drugs on behaviors (19,20). After 15-and 30-min administrations, respectively, oxycodone (100 mg/kg, s.c.) and morphine (200 mg/kg, s.c.) markedly reduced the locomotor times on the rod compared with FBC saline-treated mice (Fig.…”

Section: Effects Of Opioids On the Motor Coordination Of Fbc Model Micementioning

confidence: 99%

Effect of the Norepinephrine Transporter (NET) Inhibition on μ-Opioid Receptor (MOR)-Induced Anti-nociception in a Bone Cancer Pain Model

et al. 2014

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Abstract. Although norepinephrine transporter (NET) inhibition has an additional effect on mopioid receptor (MOR)-mediated anti-nociception in inflammatory and neuropathic pain, its effect on cancer pain is not well characterized. We investigated the additional effect of NET inhibition on MOR activation using a mouse femur bone cancer (FBC) pain model by comparing the antinociceptive effect of the dual-acting opioids tramadol and tapentadol and the clinically used MOR-targeted opioids oxycodone and morphine. The anti-nociceptive effects of subcutaneously administered opioids were assessed using the von-Frey filament test. Oxycodone (1 -10 mg/kg) and morphine (5 -50 mg/kg) dose-dependently exhibited potent anti-nociceptive effects, whereas tramadol (10 -56 mg/kg) and tapentadol (10 -30 mg/kg) exhibited partial effects. Rota-rod analyses of tapentadol at a higher dose (> 30 mg/kg) showed a significant decrease in motor coordination, which was partially recovered by pretreatment with MOR or a 1 -adrenoceptor antagonists. The partial anti-nociceptive effect of tapentadol (30 mg/kg) was completely suppressed by a MOR antagonist, but not by a 1 -or a 2 -adrenoceptor antagonists, suggesting that neither a 1 -adrenoceptor-nor a 2 -adrenoceptor-mediated pathways are involved in anti-nociception in the FBC model. We conclude that addition of NET inhibition does not contribute to MORmediated anti-nociception in bone cancer pain.

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Section: Effects Of Opioids On the Motor Coordination Of Fbc Model Micementioning

confidence: 99%

Effect of the Norepinephrine Transporter (NET) Inhibition on μ-Opioid Receptor (MOR)-Induced Anti-nociception in a Bone Cancer Pain Model

et al. 2014

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“…Twenty-four hours before the experiment, all mice were habituated to running in a rota-rod at a speed of 36 rpm for 3 minutes. The latency to fall and falling frequency were recorded 30 min after administration (Farkas et al, 2005;Lee et al, 2006).…”

Section: Rota-rod Testmentioning

confidence: 99%

Anticonvulsant Effect of Artemisia capillaris Herba in Mice

Woo¹,

Yoon²,

Peña³

et al. 2011

Biomolecules and Therapeutics

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In the present study, the anticonvulsant effects of Artemisia capillaris Herba (AC) and its major constituent, esculetin (ECT), were tested and the mechanism studied. Locomotion, Myorelaxation, motor coordination and electroshock seizure experiment were conducted in mice. To identify the anticonvulsant mechanism effect of this drug, chemical-induced seizure in mice and the ionic movement in neuroblastoma cells were also observed. The ethanol extract of AC was orally administered to mice 30 min. prior to testing and ECT was intraperitoneally injected. AC and ECT treatment did not change locomotor activities as well as activities on the rota-rod, which indicates that they did not cause a sedative and myorelaxation effect. AC and ECT treatment increased threshold of convulsion induced by electroshock. AC treatment also inhibited convulsion induced by pentylenetetrazole. In the case of strychnine however, only high dose of AC treatment inhibited convulsion. AC and ECT treatment increased the Cl − infl ux into the intracellular area in a dose-dependent manner. On the other hand, bicuculline, a GABA antagonist, inhibited the Cl − infl ux induced by AC and ECT. These results indicate that ECT induces the anticonvulsive effect of AC extract through the GABAergic neuron.

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“…Twenty-four hours before the experiment, all mice were habituated to running on the rota-rod at a speed of 60 rpm until they could remain there for 60 s without falling. The latency to the first fall was recorded and falling frequency was also measured for 20 minutes using a stopwatch Farkas et al, 2005).…”

Section: Rota-rod Evaluationmentioning

confidence: 99%

The Scutellaria Flavone, Oroxylin A, Improves Attention-Deficit/Hyperactivity Disorder Related Behaviors in Spontaneously Hypertensive Rats

Yoon¹,

Chun²,

Lee³

et al. 2008

Biomolecules and Therapeutics

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− Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean medicine. In this study, we investigated the psychopharmacological activities of oroxylin A using the open field, rota-rod, balanced wire and plus-maze tests in Spontaneously Hypertensive Rats (SHR) and Wistar Kyoto Rats (WKY). Oroxylin A reduced hyperactivity in SHR (ADHD animal model) although it tended to increase locomotor activity in WKY. Methylphenidate did not reduce hyperactivity. Oroxylin A alleviated impulsive behaviors such as rearing, the percentage of moving time to the central area and the tendency to move into an unstable condition (open area in elevated plus-maze). Methylphenidate also reduced the percentage of staying time in the central area and the tendency to move into an unstable condition. Both oroxylin A and methylphenidate enhanced motor attention in SHR and WKY. Oroxylin A antagonized the muscimol (GABA A receptor agonist)-induced Cl -current and its action was similar to that of bicuculline (GABA A receptor antagonist). The effects of oroxylin A may be caused by the antagonism at the GABA A receptor. Thus, oroxylin A may be a candidate of drug for treatment of ADHD.

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Simple pharmacological test battery to assess efficacy and side effect profile of centrally acting muscle relaxant drugs

Cited by 37 publications

References 27 publications

Effect of the Norepinephrine Transporter (NET) Inhibition on μ-Opioid Receptor (MOR)-Induced Anti-nociception in a Bone Cancer Pain Model

Effect of the Norepinephrine Transporter (NET) Inhibition on μ-Opioid Receptor (MOR)-Induced Anti-nociception in a Bone Cancer Pain Model

Anticonvulsant Effect of Artemisia capillaris Herba in Mice

The Scutellaria Flavone, Oroxylin A, Improves Attention-Deficit/Hyperactivity Disorder Related Behaviors in Spontaneously Hypertensive Rats

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