2020
DOI: 10.1371/journal.pone.0227175
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Simple non-mydriatic retinal photography is feasible and demonstrates retinal microvascular dilation in Chronic Obstructive Pulmonary Disease (COPD)

Abstract: Background Chronic Obstructive Pulmonary Disease (COPD) is associated with an increased risk of myocardial infarction and stroke but it remains unclear how to identify microvascular changes in this population. Objectives We hypothesized that simple non-mydriatic retinal photography is feasible and can be used to assess microvascular damage in COPD. Methods Novel Vascular Manifestations of COPD was a prospective study comparing smokers with and without COPD, matched for age. Non-mydriatic, retinal fundus photog… Show more

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Cited by 5 publications
(5 citation statements)
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“…There is evidence that COPD and reduced lung function is associated with micro and macrovascular damage that could mediate the relationship. [30][31][32] It is possible that vascular dementia is causally linked to COPD and lung function, but this outcome was not included in our analysis which was restricted to AD only. Cognitive dysfunction and MCI are well described in COPD.…”
Section: Discussionmentioning
confidence: 99%
“…There is evidence that COPD and reduced lung function is associated with micro and macrovascular damage that could mediate the relationship. [30][31][32] It is possible that vascular dementia is causally linked to COPD and lung function, but this outcome was not included in our analysis which was restricted to AD only. Cognitive dysfunction and MCI are well described in COPD.…”
Section: Discussionmentioning
confidence: 99%
“…We found no relationships between retinal and kidney microvascular markers and brain MRI markers. This was unexpected, given that previous studies reported retinal microvascular changes in chronic smokers and COPD patients [45,46] and moderate associations between…”
Section: Plos Onementioning
confidence: 79%
“…There is evidence that COPD and reduced lung function is associated with micro and macrovascular damage that could mediate the relationship. (31-33) It is possible that vascular dementia is causally linked to COPD and lung function, but this outcome was not included in our analysis which was restricted to Alzheimer’s disease only. Cognitive dysfunction and Mild Cognitive Impairment are well described in COPD (6) .…”
Section: Discussionmentioning
confidence: 99%