Simple Non-Invasive Method to Obtain Dna for Gene Analysis

Lench, Nicholas; Stanier, Philip; Williamson, Robert

doi:10.1016/s0140-6736(88)92178-2

Cited by 282 publications

(160 citation statements)

References 9 publications

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“…Genomic DNA was collected and isolated from buccal swabs using published procedures (Freeman et al, 1997;Lench, Stanier & Williamson, 1988). The 48 basepair VNTR in exon 3 of the DRD4 gene was assayed using modifications of previously reported methods (Sander et al, 1997).…”

Section: Candidate Genotypingmentioning

confidence: 99%

Associations of the dopamine D4 receptor gene VNTR polymorphism with drug use in adolescent psychiatric inpatients

McGeary¹,

Esposito‐Smythers²,

Spirito³

et al. 2007

Pharmacology Biochemistry and Behavior

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Background-The VNTR polymorphism in the Dopamine D4 receptor gene (DRD4) has been associated with differential urge for substances across multiple methodologies ranging from neuroimaging to assessment in the natural environment. It is unclear whether the DRD4 gene is a marker for an underlying propensity for greater urge or whether the DRD4 gene differentially moderates the neuroadaptive effects of extended substance use on urge. Examination of the DRD4 in an adolescent sample may provide evidence of a mechanism of this putative relationship.

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Section: Candidate Genotypingmentioning

confidence: 99%

Associations of the dopamine D4 receptor gene VNTR polymorphism with drug use in adolescent psychiatric inpatients

McGeary¹,

Esposito‐Smythers²,

Spirito³

et al. 2007

Pharmacology Biochemistry and Behavior

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show abstract

“…Genomic DNA was collected at baseline and isolated from buccal cells using published procedures (Lench et al, 1988). The 48 bp VNTR in the third exon of the DRD4 was assayed using previously reported methods (Sander et al, 1997).…”

Section: Dna Extraction and Genetic Analysismentioning

confidence: 99%

Olanzapine Reduces Craving for Alcohol: A DRD4 VNTR Polymorphism by Pharmacotherapy Interaction

Hutchison

Wooden

Swift

et al. 2003

Neuropsychopharmacol

108

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Separate investigations have suggested that olanzapine, a D4 antagonist, decreases craving after a priming dose of alcohol and that the DRD4 variable number of tandem repeats (VNTR) polymorphism influences the expression of craving after a priming dose of alcohol. The present study tested the hypothesis that olanzapine may be differentially effective at reducing cue-elicited craving based on individual differences in DRD4 VNTR in a sample of heavy social drinkers. Participants were randomly assigned to receive olanzapine (5 mg) or a control medication (cyproheptadine, 4 mg) prior to consuming three alcoholic drinks. Participants completed subjective measures of craving and euphoria after each drink. Participants who were homozygous or heterozygous for the 7 (or longer) repeat allele of the DRD4 VNTR were classified as DRD4 L, while the other participants were classified as DRD4 S. The findings indicated that olanzapine reduces craving for alcohol at baseline for both DRD4 S and DRD4 L individuals, but only reduces craving after exposure to alcohol cues and after a priming dose of alcohol for DRD4 L individuals.

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“…If the method is coupled with boiling extraction of DNA samples (21), analysis can be performed within a day.…”

Section: Discussionmentioning

confidence: 99%

Rapid Diagnosis of Familial Defective Apolipoprotein B-100

Geisel

Schleifenbaum²,

Weißhaar³

et al. 1991

Clinical Chemistry and Laboratory Medicine

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Simple Non-Invasive Method to Obtain Dna for Gene Analysis

Cited by 282 publications

References 9 publications

Associations of the dopamine D4 receptor gene VNTR polymorphism with drug use in adolescent psychiatric inpatients

Associations of the dopamine D4 receptor gene VNTR polymorphism with drug use in adolescent psychiatric inpatients

Olanzapine Reduces Craving for Alcohol: A DRD4 VNTR Polymorphism by Pharmacotherapy Interaction

Rapid Diagnosis of Familial Defective Apolipoprotein B-100

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