Simple nasal polyps and allergic manifestations

Polypoid changes of the middle turbinate as an indicator of atopic disease

“…Another study demonstrated that the association between nasal polyps and asthma was strong, but not associated with atopic status demonstrated by skin‐prick allergy testing . An additional prospective study could not associate atopy with nasal polyps . Newer research has shown that there is evidence of local production of IgE in polypoid tissue, but still no direct association with positive serum allergy testing has been shown .…”

Central Compartment Atopic Disease

“…With regard to CRSwNP, a prospective study from 1978 did not find an association between atopy and nasal polyposis, 17 whereas more recent literature has focused on the strong evidence for the local expression of total and allergen-specific IgE in polypoid tissue. 18 Pumhirun et al 5 performed skin-prick testing on 40 patients with nasal polyps and 30 control subjects, and found that 60% of patients with nasal polyps had positive skin-prick testing results compared with only 20% in the control group (p ϭ 0.0019).…”

Mast cell quantitation in nasal polyps, sinus mucosa and nasal turbinate mucosa

“…These findings suggest that allergic mechanisms may contribute to the development of nasal polyps. Some investigators have tried to divide patients with nasal polyps into allergic and infective groups; however, the degree of eosinophil infiltration and histamine content do not clearly distinguish between the two groups (Busutil et al, 1978;Small et al, 1981;Drake-Lee and McLaughlin, 1982;Drake-Lee et al, 1984). Although a high level of histamine has been reported in nasal polyps (Bumsted et al, 1979), there are few details concerning the distribution and abundance of mast cells in nasal polyp tissue.…”