Simple model of surface-induced electrolytic dissociation of weak acids in organic solvents

Kosmulski, Marek

doi:10.1007/s10450-010-9239-9

Cited by 7 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, the higher solubility of precursors in water leads to the insoluble HA phase produced in water. Furthermore, the p K a value in water (p K a = 2.11) indicates a higher dissociation of phosphoric acid than in alcohol (p K a = 5.15–6.15), which shifts the reaction from left to right (eq ) and more HPO 4 2– ions favor brushite and then HA formation in water In addition, the Ca/P ratio of these phases and the solubility of precursors are intimately related.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Phase-Tunable Calcium Phosphate Biomaterials Synthesis and Application in Protein Delivery

Lau

Reardon

Knowles

et al. 2015

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Calcium phosphates (CaP) are important biomaterials used in tissue engineering and drug delivery, due to their biocompatibility, low toxicity, and osteoconductivity. However, controlling the phase of CaP, especially tricalcium phosphate (TCP), is very challenging under mild conditions, particularly when using one preparation protocol for all CaP phases. It is also crucial to produce these biomaterials economically and reproducibly. Herein, three of the most commonly employed CaP, including beta-tricalcium phosphate (β-TCP), dicalcium phosphate anhydrous (DCPA), and hydroxyapatite (HA) were, for the first time, successfully synthesised by altering the reaction solvent, using calcium acetate monohydrate as a precursor and a rapid microwave-assisted synthetic method. A variety of CaP particle morphologies were obtained, including elliptical and plate-shaped with different porosities. Compared with conventional heating, CaP biomaterials synthesised using microwave heating showed greater reproducibility, higher yields, and shorter reaction time. By varying the reaction solvents, morphologies and phases of CaP were controlled, leading to an enhanced protein bovine serum albumin (BSA) loading, with a higher BSA absorption observed according to the trend DCPA> β-TCP > HA. Furthermore, the phase, specific surface area and pores size were shown to play decisive roles in protein desorption with a higher release amount observed according to the trend DCPA > β-TCP

show abstract

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the pK a value in water (pK a =2.11) indicates a higher dissociation of phosphoric acid than in alcohol (pK a = 5.15-6.15), which shifts the reaction from left to right (Equation 4) and more H 4 2− ions favour brushite and then HA formation in water. 35…”

Section: Dcpa (Equation 2)mentioning

confidence: 99%