Simple methodology of assessment of analgesics' addictive potential in mice

Пчелинцев, М. В.; Gorbacheva, Elvira N.; Zvartau, Edwin

doi:10.1016/0091-3057(91)90046-5

Cited by 24 publications

(12 citation statements)

References 4 publications

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“…Rewarding effects of morphine were revealed in wild-type mice, as previously reported (Pchelintsev et al, 1991), but these effects were absent in mice lacking the A 2A receptor, under the current experimental paradigm. The possibility of a learning impairment is unlikely, as both A 2A knockout and Figure 5 Conditioned place preference to morphine (10 mg/kg, i.p.)…”

Section: Discussionsupporting

confidence: 65%

A Differential Role for the Adenosine A2A Receptor in Opiate Reinforcement vs Opiate-Seeking Behavior

Brown

Short²,

Cowen

et al. 2008

Neuropsychopharmacol

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The adenosine A 2A receptor is specifically enriched in the medium spiny neurons that make up the 'indirect' output pathway from the ventral striatum, a structure known to have a crucial, integrative role in processes such as reward, motivation, and drug-seeking behavior. In the present study we investigated the impact of adenosine A 2A receptor deletion on behavioral responses to morphine in a number of reward-related paradigms. The acute, rewarding effects of morphine were evaluated using the conditioned place preference paradigm. Operant self-administration of morphine on both fixed and progressive ratio schedules as well as cue-induced drug-seeking was assessed. In addition, the acute locomotor response to morphine as well as sensitization to morphine was evaluated. Decreased morphine selfadministration and breakpoint in A 2A knockout mice was observed. These data support a decrease in motivation to consume the drug, perhaps reflecting diminished rewarding effects of morphine in A 2A knockout mice. In support of this finding, a place preference to morphine was not observed in A 2A knockout mice but was present in wild-type mice. In contrast, robust cue-induced morphine-seeking behavior was exhibited by both A 2A knockout and wild-type mice after a period of withdrawal. The acute locomotor response to morphine in the A 2A knockout was similar to wild-type mice, yet A 2A knockout mice did not display tolerance to chronic morphine under the present paradigm. Both genotypes display locomotor sensitization to morphine, implying a lack of a role for the A 2A receptor in the drug-induced plasticity necessary for the development or expression of sensitization. Collectively, these data suggest a differential role for adenosine A 2A receptors in opiate reinforcement compared to opiate-seeking.

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Section: Discussionsupporting

confidence: 65%

A Differential Role for the Adenosine A2A Receptor in Opiate Reinforcement vs Opiate-Seeking Behavior

Brown

Short²,

Cowen

et al. 2008

Neuropsychopharmacol

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“…This observation strongly suggests that the reported lack of CPP effects at higher buprenorphine doses in previous studies (Brown et al 1991;Pchlintsev et al 1991;Rowlett et al 1994) was due to temporal constraints of the experimental design. In these studies, buprenorphine at doses higher than 1.0 mg/ kg (Rowlett et al 1994) or 0.3 mg/kg (Brown et al 1991) did not produce CPP.…”

Section: Cpp Effects Of Buprenorphinementioning

confidence: 48%

“…Previous reports (Brown et al 1991;Pchlintsev et al 1991;Rowlett et al 1994) have shown that the rewarding effects of buprenorphine as determined in conditioned place preference (CPP) also follow an inverted U-shaped dose-response function (although it should be noted that one study has found CPP that was not dose-dependent; Gaiardi et al 1997). In all of these studies a "standard" conditioning procedure was used in which drug administration and conditioning, and vehicle administration and conditioning were done on alternating days, leaving approximately 24 h for washout of the drug before the next vehicle session.…”

Section: Introductionmentioning

confidence: 91%

Reassessment of buprenorphine in conditioned place preference: temporal and pharmacological considerations

Tzschentke

2004

Psychopharmacology

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The present results suggest that the reported lack of CPP effects at high doses of buprenorphine may be due to factors in the experimental design, resulting in a carry-over effect from drug- to vehicle conditioning. They also suggest that buprenorphine, like other opiates, produces its CPP effects via micro -receptors, although kappa-antagonistic mechanisms also appear to be involved. The implications of these findings for the safety of buprenorphine for human use are discussed.

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“…Using a biased conditioning design and subcuntaneous drug administration, Pchelintsev et al (1991) showed that in mice buprenorphine produced a dose-dependent CPP with an inverted U-shaped dose-response curve (increasing CPP in the range of 0.05-0.1 mg/kg, with decreasing effects at higher doses; maximum effect at 0.1 mg/kg). The ED 50 for the CPP effect was approximately equal to the ED 50 found for analgesia in the writhing test.…”

Section: Conditioned Place Preference (Cpp)mentioning

confidence: 99%

Behavioral pharmacology of buprenorphine, with a focus on preclinical models of reward and addiction

Tzschentke¹

2002

Psychopharmacology

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Since buprenorphine is a potent opioid drug, the issue of addiction and dependence in this context is an important one. Although there are still some gaps in the behavioral pharmacological characterization of buprenorphine, the general conclusion that can be drawn from the reviewed literature is that despite the high affinity of buprenorphine for the mu receptor it appears to be a remarkably safe drug, with a benign overall side effect profile and low addictive and dependence-inducing potential. This favorable side effect profile appears to be due, to a large extent, to the partial agonistic properties of the drug, in combination with its particular receptor kinetics (i.e. very slow dissociation from the mu receptor after binding).

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Simple methodology of assessment of analgesics' addictive potential in mice

Cited by 24 publications

References 4 publications

A Differential Role for the Adenosine A2A Receptor in Opiate Reinforcement vs Opiate-Seeking Behavior

A Differential Role for the Adenosine A2A Receptor in Opiate Reinforcement vs Opiate-Seeking Behavior

Reassessment of buprenorphine in conditioned place preference: temporal and pharmacological considerations

Behavioral pharmacology of buprenorphine, with a focus on preclinical models of reward and addiction

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