Simple method to make a supersaturated oxygen fluid

Tange, Yoshihiro; Yoshitake, Shinji; Takesawa, Shingo

doi:10.1007/s10047-018-1022-9

Cited by 4 publications

(5 citation statements)

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“…We demonstrated that the pO 2 and DO 2 in the blood increase significantly using a saturated oxygen solution. Our findings supported the results of the previous studies [7,10,11]. Critically ill patients with hypoxia need blood oxygenation.…”

Section: Discussionsupporting

confidence: 93%

“…Preparing saturated oxygen solutions has been considered difficult because of the need of original devices [10][11][12]. However, we developed a saturated oxygen solution using a simple method [7]. This method resulted in the increase in the pO 2 more than 500 mmHg.…”

Section: Discussionmentioning

confidence: 99%

“…We developed a solution saturated with dissolved oxygen using a simple method, and observed increases in the pO 2 and total oxygen content (CaO 2 ) in the blood in vitro using this solution [7]. Applying this method to the supplemental bicarbonate dialysis fluid, a significant increase in the pO 2 and simultaneous decrease in the partial pressure of carbon dioxide (pCO 2 ) were observed [8].…”

Section: Introductionmentioning

confidence: 99%

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Oxygen delivery to the blood stream by the dialysis fluid during continuous renal replacement therapy ex vivo

Tange

Yoshitake

2019

J Artif Organs

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Continuous renal replacement therapy (CRRT) maintains a balance in body water and electrolytes. CRRT supplies a higher quantity of fluid than intravenous fluid therapy along with simultaneous fluid withdrawal. We hypothesized that use of a high-oxygen-containing solution for high-volume fluid exchange would improve oxygenation in the blood during CRRT. To start with, we prepared a solution containing high oxygen. The objective of this study was to determine if this solution would increase the partial pressure of oxygen (pO 2) in the blood more than that using a conventional solution during CRRT. We compared the gas profile of the experimental fluid ex vivo in a simulated CRRT for 24 h, using 2-L batches of bovine blood. A significant increase in the pO 2 , pH, and total oxygen delivery, and a significant decrease in the partial pressure of carbon dioxide (pCO 2) were estimated in the bovine blood using the experimental solution during the simulated CRRT. This method is simpler to apply for oxygenation than the conventional method, and will be beneficial to hypoxic patients in terms of improving their blood oxygenation during CRRT.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oxygen delivery to the blood stream by the dialysis fluid during continuous renal replacement therapy ex vivo

Tange

Yoshitake

2019

J Artif Organs

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“…The oxygen tension of the liquid is expected to approach 150 mmHg when the diffusion of oxygen in contact with air reaches equilibrium by Henry’s and Fick’s law [(atmospheric pressure - water vapor pressure at 37°C)×F I O 2 : (760-47)×0.21≒150]. The PaO 2 of a small amount of bovine blood mixed with a saline solution equilibrated under air has been reported to be 165.8 ± 1.2 mmHg [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Intermittent Urine Oxygen Tension Monitoring for Predicting Acute Kidney Injury After Cardiovascular Surgery: A Preliminary Prospective Observational Study

Kato¹,

Kawasaki²,

Koyama³

2021

Cureus

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IntroductionNovel biomarkers of acute kidney injury (AKI) are being developed and commercialized. However, none are universally available. The aim of this preliminary prospective observational study was to explore the effectiveness of intermittent urine oxygen tension (PuO 2 ) monitoring without special equipment (using a blood gas analyzer) for predicting AKI after elective cardiovascular surgery requiring cardiopulmonary bypass (CPB). MethodsFifty patients who underwent elective cardiovascular surgery requiring CPB were enrolled in the study with written informed consent. Urine samples were intermittently collected from a urethral catheter at four points: T1, immediately after induction of general anesthesia in the operating room; T2, immediately after intensive care unit (ICU) admission; T3, six hours after ICU admission; and T4, 12 hours after ICU admission. PuO 2 was measured with a blood gas analyzer. The Kidney Disease Improving Global Outcomes classification was used for the diagnosis of AKI, then patients were followed up until postoperative day 7. By generating the receiver operating characteristic curves, the cut-off value of PuO 2 and area under the curve (AUC) for predicting the onset of AKI was calculated. The odds ratio (OR) and 95% confidence interval (CI) of each time point were calculated using logistic regression analysis or exact logistic regression method. P < 0.05 was considered significant. ResultsTwelve patients were diagnosed with AKI (24% morbidity). The cut-off values of PuO 2 for predicting onset of AKI at the four time points were T1, PuO 2 ≥ 132.4 mmHg (OR 3.1, 95% CI 0.78-12.0, p = 0.11, AUC 0.57); T2,

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“…The data presented here shows production of a solution that contains NO with reference to an article [1]. The supplemental fluid (Sublood BSG, Fuso) was used as the test solution.…”

Section: Data Descriptionmentioning

confidence: 99%

Data on producing an infusion fluid that contains nitric oxide

2020

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Nitric oxide (NO) is a vasodilator and platelet aggregation inhibitor. In patients with pulmonary hypertension, inhalation of NO is used as a therapeutic option. It has been proposed that nitrite (NO2−) is a constitute intravascular storage and delivery source of NO, a potent cardioprotective-signaling molecule. The administration of NO2− could have therapeutic effects in conditions where the oxygen-dependent enzymatic production of NO is compromised (i.e., ischemia). Thus, if NO could be supplied by an intravenous infusion fluid, it would be an easier method than by inhalation or delivery to the blood vessels by the blood stream. We produced 2 types of solutions, i.e., a nitrogen gas injected solution (control solution) and NO gas injected solution (experimental solution). NO was measured by the Microplate Photometer (MultiSkan FC, Thermo Fisher Scientific K.K., Tokyo, Japan) with a 540-nm wavelength and NO assay kit (Quantichrom™ Nitric Oxide Assay Kit, BioAssay Systems, Hayward, CA, USA). Gas profiles were measured by the EG6+ (Abbott Japan Co., Ltd., Osaka, Japan) with an i-STAT system (300F, Abbott Japan Co., Ltd.). Comparisons of gas profiles and measured NO concentrations in vitro and ex vivo are shown between the control and experimental solutions. Since NO is oxidized to NO2− and nitrate (NO3−), it is common practice to quantitate total NO2−/NO3− as a measure of the NO level. We used the assay that was designed to accurately measure NO production following reduction of NO3− to NO2− using the Griess method. The data in this document describe production of an infusion fluid that contains NO without any special devices.

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Simple method to make a supersaturated oxygen fluid

Cited by 4 publications

References 5 publications

Oxygen delivery to the blood stream by the dialysis fluid during continuous renal replacement therapy ex vivo

Oxygen delivery to the blood stream by the dialysis fluid during continuous renal replacement therapy ex vivo

Intermittent Urine Oxygen Tension Monitoring for Predicting Acute Kidney Injury After Cardiovascular Surgery: A Preliminary Prospective Observational Study

Data on producing an infusion fluid that contains nitric oxide

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