1997
DOI: 10.1016/s0021-9673(96)00921-1
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Simple liquid chromatographic method for the analysis of 5-aminosalicyclic acid and its degradation product

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Cited by 15 publications
(7 citation statements)
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“…Samples from the pH-gradient method and the biorelevant release tests were analysed using a validated method (Haney & Dash 1997) on a Lichrosorb RP-8, 5 , 125 Â 4 mm column (Merck, Darmstadt, Germany) using methanol-phosphate buffer pH 7.4 (20:80%) as mobile phase. The flow rate was set at 1.0 mL min À1 and detection was at 331 nm.…”
Section: Mesalazinementioning
confidence: 99%
“…Samples from the pH-gradient method and the biorelevant release tests were analysed using a validated method (Haney & Dash 1997) on a Lichrosorb RP-8, 5 , 125 Â 4 mm column (Merck, Darmstadt, Germany) using methanol-phosphate buffer pH 7.4 (20:80%) as mobile phase. The flow rate was set at 1.0 mL min À1 and detection was at 331 nm.…”
Section: Mesalazinementioning
confidence: 99%
“…Intra-day variability showed a mean RSD of 2.51%. Haney and Dash (1997) validated the HPLC method for 5-ASA assay and the intra and inter-day precisions obtained were 1.2-4.6% and 1.1-3.5%, respectively.…”
Section: Hplc Methodsmentioning
confidence: 88%
“…1) (5-amino-2-hydroxybenzoic acid) is an anti-inflammatory drug used to treat and also maintain the remission of mild to moderate ulcerative colitis or Crohn's disease (17,18 Mesalazine has been shown to be a potent scavenger of reactive oxygen species that plays a significant role in the pathogenesis of inflammatory bowel disease, inhibition of natural killer cell activity, inhibition of antibody synthesis, inhibition of cyclo-oxygenase and lipoxygenase pathways and impairment of neutrophil function (19). Several analytical methods have been reported for the determination of MSZ in pharmaceutical dosage forms and biological fluids including micellar electrokinetic chromatography (20), differential pulse voltammetry (21) high pressure liquid chromatography (HPLC) (22)(23)(24)(25)(26)(27), liquid chromatography-tandem mass spectrometry (LC-MS/MS) (28) and spectrophotometric analysis (29)(30)(31)(32). However, only a few spectrofluorometric methods (33,34) have been reported for the determination of MSZ in its pharmaceutical formulations.…”
Section: Introductionmentioning
confidence: 99%