Simple Indolizidine and Quinolizidine Alkaloids

Michael, Joseph P.

doi:10.1016/bs.alkal.2014.12.001

Cited by 69 publications

(66 citation statements)

References 882 publications

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“…The pyrrolidine moiety is an important structural part of many natural alkaloids [1,2,3,4] and one of the most frequently occurring heterocyclic scaffolds in approved drugs [5]. A number of anti-cancer drugs possess an N -carboxypyrrolidine scaffold.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Novel 2-(Het)arylpyrrolidine Derivatives and Evaluation of Their Anticancer and Anti-Biofilm Activity

et al. 2019

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A library of novel 2-(het)arylpyrrolidine-1-carboxamides were obtained via a modular approach based on the intramolecular cyclization/Mannich-type reaction of N-(4,4-diethoxybutyl)ureas. Their anti-cancer activities both in vitro and in vivo were tested. The in vitro activity of some compounds towards M-Hela tumor cell lines was twice that of the reference drug tamoxifen, whereas cytotoxicity towards normal Chang liver cell did not exceed the tamoxifen toxicity. In vivo studies showed that the number of surviving animals on day 60 of observation was up to 83% and increased life span (ILS) was up to 447%. Additionally, some pyrrolidine-1-carboxamides possessing a benzofuroxan moiety obtained were found to effectively suppress bacterial biofilm growth. Thus, these compounds are promising candidates for further development both as anti-cancer and anti-bacterial agents.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Novel 2-(Het)arylpyrrolidine Derivatives and Evaluation of Their Anticancer and Anti-Biofilm Activity

et al. 2019

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“…In 1999, the castanospermine existing naturally as saccharide was identi ied in LCMS analysis of the same plant's crude extract. Castanospermine and its derivative celgosivirare are currently used for the treatment of Hepatitis C virus, HIV-1, and dengue virus (Michael, 2016).…”

Section: Indolizidine and Quinolizidine Alkaloidsmentioning

confidence: 99%

Plant-derived alkaloids as anti-viral agents

Krishnan

Velmurugan

Pachaiappan

2020

ijrps

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Humans are prone to many viral infections, most of them not causing diseases, and some will do. The new pandemic situation in global development and comfort to travel have highlighted their protection as a crucial problem in people’s health and safety even though significant advancements are being made in the making of vaccines and drugs. The provenance of viral mutants generally threatens immunisation and effective anti-viral treatments. The discovery of novel anti-viral drugs is, therefore of paramount importance. The secondary metabolites from the plants with pharmacological activities are regarded as an exemplary repository for this diagnosis. An extensive study of phytochemicals and their mechanisms of action against the viruses might help in controlling harmful viruses. Many phytochemical entities, including terpenes, flavonoids, polyphenol, and phenolic compounds, have been studied for their anti-viral activity. Particularly in alkaloids, cutting edge study is making way to uncover innovative therapeutic strategies. Most of the alkaloids are being used as anti-viral agents, act against few prominent viral pathogens such as coronavirus (CoV), human immune deficiency virus (HIV), systemic acute respiratory syndrome (SARS) and respiratory virus (RSV). In this review, we intend to summarise the medicinal use of plant-derived alkaloids utilised to cure viral diseases in the past four decades.

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“…Indolizidines: Indolizidine alkaloids represent another large group of natural products of manifold biological activities [115]. For example, swainsonine is known as mannosidase inhibitor and it also has a potential in chemotherapy [116].…”

Section: Reviewmentioning

confidence: 99%

N-(1-Phenylethyl)aziridine-2-carboxylate esters in the synthesis of biologically relevant compounds

Głowacka¹,

Trocha²,

Wróblewski³

et al. 2019

Beilstein J. Org. Chem.

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Since Garner’s aldehyde has several drawbacks, first of all is prone to racemization, alternative three-carbon chirons would be of great value in enantioselective syntheses of natural compounds and/or drugs. This review article summarizes applications of N-(1-phenylethyl)aziridine-2-carboxylates, -carbaldehydes and -methanols in syntheses of approved drugs and potential medications as well as of natural products mostly alkaloids but also sphingoids and ceramides and their 1- and 3-deoxy analogues and several hydroxy amino acids and their precursors. Designed strategies provided new procedures to several drugs and alternative approaches to natural products and proved efficiency of a 2-substituted N-(1-phenylethyl)aziridine framework as chiron bearing a chiral auxiliary.

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Simple Indolizidine and Quinolizidine Alkaloids

Cited by 69 publications

References 882 publications

Synthesis of Novel 2-(Het)arylpyrrolidine Derivatives and Evaluation of Their Anticancer and Anti-Biofilm Activity

Synthesis of Novel 2-(Het)arylpyrrolidine Derivatives and Evaluation of Their Anticancer and Anti-Biofilm Activity

Plant-derived alkaloids as anti-viral agents

N-(1-Phenylethyl)aziridine-2-carboxylate esters in the synthesis of biologically relevant compounds

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