Simple indole alkaloids and those with a non-rearranged monoterpenoid unit

Abstract

This review covers newly isolated simple indole alkaloids, structure determinations, total syntheses and biological activities reported in the literature in 2003.

Recent advances in the application of indoles in multicomponent reactions

“…Indole scaffolds have been known for their value in the development of new compounds of pharmaceutical interest. [18][19][20] Up to date, several 21,22 Herein, in continuation of our studies towards the synthesis of heterocyclic compounds and multicomponent reactions, [23][24][25][26][27][28][29][30][31][32] and since there is a wide range of reactions that include indole in the preparation of heterocyclic compounds, this review presents the recent applications of indole in the synthesis of diverse heterocyclic compounds during the period from 2012 to 2017. This review rst discusses indoles' C-3 carbon atom reactivity applicable to electrophilic reactions, followed by MCRs in which the N position of indole is reacted as a nucleophile to afford N-substituted indole products.…”

Microwave-Assisted Natural Product Chemistry

“…Because of the large number of biologically interesting natural products bearing highly functionalized indole skeletons [47][48][49], Fischer indole synthesis has received considerable synthetic interest. As a consequence, microwave-assisted Fischer indole synthesis has recently been investigated as a key step in the synthesis of a large number of indole alkaloids and their structural analogues.…”

Samarium Diiodide Induced Cyclizations of γ‐, δ‐ and ε‐Indolyl Ketones: Reductive Coupling, Intermolecular Trapping, and Subsequent Transformations of Indolines

“…[12] An obvious extension of the described SmI 2 -induced cyclization-dearomatization reaction involved the employment of N-heteroaromatic ring systems, such as quinoline, [13] pyrrole, and indole derivatives. [14] The general importance of N-heterocycles, of indole derivatives in particular, [15] originates from their ubiquitous presence in natural products and pharmaceutically relevant compounds. Among these, strychnos alkaloids belong to the most fascinating indole derivatives.…”