Simple, high yielding synthesis of trifunctional fluorescent lanthanide chelates

Griffin, John M. M.; Skwierawska, Anna; Manning, H. Charles; Marx, John N.; Bornhop, Darryl J.

doi:10.1016/s0040-4039(01)00620-7

Cited by 23 publications

(12 citation statements)

References 16 publications

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“…These exogenous agents can be categorized in two major types: nonspecific and specific to cellular targets [157]. BODIPY [158] and lanthanide chelates [159] are examples of hybrid optical agents. Cyanine dyes are an important class of optical agents, which have gained tremendous attention due to their favorable NIR optical properties (Figure 5) [160].…”

Section: Optical Imaging At the Nanoscalementioning

confidence: 99%

Nanomedicine Strategies for Molecular Targets with Mri and Optical Imaging

et al. 2010

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The science of 'theranostics' plays a crucial role in personalized medicine, which represents the future of patient management. Over the last decade an increasing research effort has focused on the development of nanoparticle-based molecular-imaging and drug-delivery approaches, emerging as a multidisciplinary field that shows promise in understanding the components, processes, dynamics and therapies of a disease at a molecular level. The potential of nanometer-sized agents for early detection, diagnosis and personalized treatment of diseases is extraordinary. They have found applications in almost all clinically relevant biomedical imaging modality. In this review, a number of these approaches will be presented with a particular emphasis on MRI and optical imaging-based techniques. We have discussed both established molecular-imaging approaches and recently developed innovative strategies, highlighting the seminal studies and a number of successful examples of theranostic nanomedicine, especially in the areas of cardiovascular and cancer therapy. Nanotechnology is starting to invade different areas of science and 'theranostic' biomedical science is no exception [1][2][3][4]. The science of theranostics plays a critical role in personalized medicine, which represents the future of patient management. Nanoparticle-based medicinal approaches have emerged as an interdisciplinary area, that shows promise in understanding the components, processes, dynamics and therapies of disease at a molecular level. The unprecedented potential of nanoplatforms for early detection, diagnosis and personalized treatment of diseases have found application in every biomedical imaging modality.These include noninvasive cellular and molecular-imaging techniques, including ultrasound (US) [5], optical [6], PET [7], computed tomography [8][9] and MRI [10][11][12][13][14].MRI is a noninvasive diagnostic technique based on the interaction of nuclei with each other and the surrounding molecules in a tissue. The sensitivity of magnetic resonance is low in comparison to nuclear and optical modalities; however, the absence of radiation (transmitted or injected) and high spatial resolution (e.g., sub-millimeter) makes it advantageous over Correspondence to: Gregory M Lanza,

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Section: Optical Imaging At the Nanoscalementioning

confidence: 99%

Nanomedicine Strategies for Molecular Targets with Mri and Optical Imaging

et al. 2010

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“…In previous work, such a system was built up with two chelating arms, a chelating chromophore and a free amine on cyclen ring, by a similar reaction between 3-chloromethyl-4-pyridothioxanthone and the cyclen derivative 1a, [2c] as reported by Bornhop. [6] In this reaction, the major product was monosubstituted cyclen rather than the di-substituted. When 3-chloromethyl-4-pyridothioxanthone was replaced with 7-bromomethyl-4-pyridothioxanthone, [8] the proportion of the di-substituted product increased dramatically.…”

Section: Resultsmentioning

confidence: 87%

“…[6] However, a tetra-substituted ligand might be the main product in this method. Wong also applied this method but using 1,4-di-protected cyclen to react with alkyl halides; only "less reactive" haloalkanes resulted in adequate yields, whereas for activated electrophiles such as benzyl halides, the undesired bis-substituted product predominated.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a Europium Complex for Anion‐Sensing Involving Regioselective Substitution of Cyclen

Parker

2005

Eur J Org Chem

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“…Aromatic h-diketones are commonly employed as sensitizers for the lanthanides, and this topic has been comprehensively reviewed by Lis et al (Lis et al, 2002). Additionally, Bornhop et al have used antenna chelators to improve lanthanide sensitization (Griffin et al, 2001;Manning et al, 2002). Fig.…”

Section: Lanthanide Luminescencementioning

confidence: 99%