Simple gangliosides co-localize with amyloid plaques and increase with age in a transgenic mouse model of Alzheimer’s disease
Wenxuan Wang,
Sarah J. Myers,
Nikita Ollen-Bittle
et al.
Abstract:Alzheimer’s disease (AD) is a progressive neurodegenerative disease accounting for two-thirds of all dementia cases, and age is the strongest risk factor. Beyond the amyloid hypothesis, lipid dysregulation is now recognized as a core component of AD pathology. Gangliosides are a class of membrane lipids of the glycosphingolipid family and are enriched in the central nervous system (CNS). Ganglioside dysregulation has been implicated in various neurodegenerative diseases, including AD, but the spatial distribut… Show more
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