Simple, fast and sensitive LC–MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites

Smoking behaviour and compensation: A review of the literature with meta-analysis

“…Irrespective of the machine-derived nicotine yield, approximately 1 mg of nicotine was absorbed per cigarette. This smoking-related nicotine dose can reliably be determined by measuring nicotine and 5 to 10 of its major metabolites (Byrd et al, 1995(Byrd et al, , 1998Curvall et al, 1990;Mendes et al, 2009;Piller et al, 2014;Scherer et al, 2007;Tricker, 2006).…”

Current research on cigarette toxicity: critical appraisal in view of clinical laboratory

“…This has led to novel development and validation of alternatives such as toenails, hairs, and detection of multiple metabolites of nicotine exposure. 19,83,85,86 However, what has not been largely discussed and adopted for the benefit of LMICs is the potential of haematological and haemorheological parameters as possible clinical diagnostic markers for cigarette toxicity.…”

A high-throughput, simultaneous analysis of carotenoids, chlorophylls and tocopherol using sub two micron core shell technology columns

“…The linearity of the regression curves provided the accuracy of the method. Precision of the chromatographic method is obtained by studying the inter-day and intra-day variations of five different broccoli cultivars as described by Piller et al, [22]. Each sample was extracted twice and injected into the UPLC system.…”

“…This procedure was repeated three times. There would be no carryover if the CV of the blank samples would fall below 20% [22].…”