Simple Determination of Iodine in Small Specimens of Thyroid Tissue<sup>1</sup>)

Tiran, Beate; Wawschinek, O.; Eber, O; Beham, Alfred; Lax, Sigurd; Dermelj, M.

doi:10.1055/s-0029-1211097

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…Prior to the analysis, the tissue was digested in a mixture of sodium chlorate and perchloric acid at 100 degrees C. Using this manner of digestion between 94 and 110% of iodine in the sample was recovered. Comparison with the neutron activation analysis showed excellent agreement of the obtained values (Tiran et al, 1991).…”

Section: Biological Fluids and Tissuessupporting

confidence: 69%

A Review of Spectrophotometric and Chromatographic Methods and Sample Preparation Procedures for Determination of Iodine in Miscellaneous Matrices

Błażewicz¹

2012

Macro to Nano Spectroscopy

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Section: Biological Fluids and Tissuessupporting

confidence: 69%

A Review of Spectrophotometric and Chromatographic Methods and Sample Preparation Procedures for Determination of Iodine in Miscellaneous Matrices

Błażewicz¹

2012

Macro to Nano Spectroscopy

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“…This procedure was adopted for a variety of biosamples . Some other chloric acid procedures additionally use perchloric and chromic acids; , appropriate precautions must be taken. Pino et al developed a procedure in which ammonium persulfate (AP) is used to digest urine.…”

Section: Sample Digestion Methods and Alternativesmentioning

confidence: 99%

Fenton Digestion of Milk for Iodinalysis

et al. 2011

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Iodine is an essential micronutrient especially important in the neurodevelopment of infants. Spot samples of urinary iodine (UI) are used as an epidemiologic index of adult iodine nutrition. Individual infant iodine nutrition is of vital importance, but infant urine is difficult to collect, much less a 24 h sample. Monitoring the intake provides a pragmatic solution for determining infant iodine nutrition. Because of the high solids content of milk and the possible existence of iodine in an organically bound form, sample digestion is obligatory. The U.S. Food and Drug Administration, for example, uses wet ashing by HClO(4); special precautions and fume hoods are required. We present a method of Fenton digestion of human and bovine milk samples and infant formula. No specialized equipment or hazardous reagents are used; measurement is made by isotope dilution inductively coupled plasma mass spectrometry. In Fenton digestion, Fe(II) and H(2)O(2) oxidizes the sample. In an interlaboratory study, excellent agreement (r(2) = 0.9934) was observed with results obtained by HClO(4) digestion and Sandel-Kolthoff kinetic colorimetry. Average recoveries of iodide, triiodothyronine, and thyroxine ranged between 100% and 101%. Following digestion, iodine was found to exist entirely as iodide. Control of pH is imperative if loss cannot be corrected for by isotope dilution. Loss was below 20% for all samples when the pH was between 2.25 and 2.5.

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“…The physiological iodine concentration in rat and human thyroid was calculated to be approximately 9.0 mM [168][169][170]. Taking into consideration the similarity between porcine and human thyroid (volume, the process of thyroid hormone synthesis) [171], it may be estimated that the concentration of iodine in porcine thyroid-broadly used in in vitro studies-is similar.…”

Section: In Vitro Studiesmentioning

confidence: 99%

Iodine as a potential endocrine disruptor—a role of oxidative stress

et al. 2022

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Purpose Iodine is an essential micronutrient required for thyroid hormone biosynthesis. However, overtreatment with iodine can unfavorably affect thyroid physiology. The aim of this review is to present the evidence that iodine—when in excess—can interfere with thyroid hormone synthesis and, therefore, can act as a potential endocrine-disrupting chemical (EDC), and that this action, as well as other abnormalities in the thyroid, occurs—at least partially—via oxidative stress. Methods We reviewed published studies on iodine as a potential EDC, with particular emphasis on the phenomenon of oxidative stress. Results This paper summarizes current knowledge on iodine excess in the context of its properties as an EDC and its effects on oxidative processes. Conclusion Iodine does fulfill the criteria of an EDC because it is an exogenous chemical that interferes—when in excess—with thyroid hormone synthesis. However, this statement cannot change general rules regarding iodine supply, which means that iodine deficiency should be still eliminated worldwide and, at the same time, iodine excess should be avoided. Universal awareness that iodine is a potential EDC would make consumers more careful regarding their diet and what they supplement in tablets, and—what is of great importance—it would make caregivers choose iodine-containing medications (or other chemicals) more prudently. It should be stressed that compared to iodine deficiency, iodine in excess (acting either as a potential EDC or via other mechanisms) is much less harmful in such a sense that it affects only a small percentage of sensitive individuals, whereas the former affects whole populations; therefore, it causes endemic consequences.

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Simple Determination of Iodine in Small Specimens of Thyroid Tissue¹)

Cited by 7 publications

References 5 publications

A Review of Spectrophotometric and Chromatographic Methods and Sample Preparation Procedures for Determination of Iodine in Miscellaneous Matrices

A Review of Spectrophotometric and Chromatographic Methods and Sample Preparation Procedures for Determination of Iodine in Miscellaneous Matrices

Fenton Digestion of Milk for Iodinalysis

Iodine as a potential endocrine disruptor—a role of oxidative stress

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Simple Determination of Iodine in Small Specimens of Thyroid Tissue1)

Cited by 7 publications

References 5 publications

A Review of Spectrophotometric and Chromatographic Methods and Sample Preparation Procedures for Determination of Iodine in Miscellaneous Matrices

A Review of Spectrophotometric and Chromatographic Methods and Sample Preparation Procedures for Determination of Iodine in Miscellaneous Matrices

Fenton Digestion of Milk for Iodinalysis

Iodine as a potential endocrine disruptor—a role of oxidative stress

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Product

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Simple Determination of Iodine in Small Specimens of Thyroid Tissue¹)