Simple chiral auxiliary-assisted resolution of 2-(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid

Magnesium-Mediated Umpolung Carboxylation of p-Quinone Methides with CO2

“…2-(3,5-Di-tert-butyl-4-hydroxyphenyl)propanoic Acid (2d′). 16 Isolated yield: 27% (22 mg) as a colorless oil (eluent: petroleum ether/EtOAc = 2:1). 1 H NMR (400 MHz, CDCl 3 ): δ 7.12 (s, 2H), 5.15 (s, 1H), 3.65 (q, J = 7.2 Hz, 1H), 1.49 (d, J = 7.2 Hz, 3H), 1.43 (s, 18H) ppm.…”