Over the past several years, work by a number of investigators [reviewed in (1)] has led to the development of a kinetic approach to the study of Ca metabolism. Because the studies have not been numerous and because of differences in experimental technique, results and interpretations based on them have differed. For example, some investigators (2-5) failed to find a difference in Ca metabolism in patients with osteoporosis as compared with normal individuals, whereas others (6) report such differences.The purpose of this report is to present findings in persons of different ages, including women with and without osteoporosis, and young people with scoliosis, studied before and after immobilization in a plaster cast. The findings were obtained by a consistent mode of analysis applied to data collected in a uniform manner. From the results, relationships have been derived between Ca absorption from the intestine and Ca deposition in bone, and between Ca deposition in and removal from bone. These relationships have been used to describe Ca metabolism as a system of interdependent vectors in dynamic equilibrium, and this description has been applied to postmenopausal osteoporosis and the events following immobilization.
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