Simple bedside tests of muscle strength and function correlate with computed tomography-skeletal muscle index for assessment of sarcopenia in cirrhosis

Singh, Surender; Taneja, Sunil; Roy, Akash; Rathi, Sahaj; De, Arka; Verma, Nipun; Premkumar, Madhumita; Duseja, Ajay; Dhiman, Radha K.; Singh, Virendra

doi:10.1007/s12664-023-01338-8

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…Muscle strength can also be assessed clinically by using simple tests such as hand grip strength (HGS) and gait speed (GS). Singh et al from Chandigarh, India, have done an elegant study to assess whether the bedside assessment of sarcopenia in the outpatient setting was almost as good as imaging to assess sarcopenia as well as predict mortality in patients with cirrhosis [7]. They found that 55% of 116 patients had sarcopenia as defined by skeletal muscle index (SMI) at CT scan.…”

Section: Bringing Sarcopenia Assessment In Cirrhosis To the Bedsidementioning

confidence: 99%

Indian Journal of Gastroenterology—May–June 2023 — highlights

Bhatia

2023

Indian J Gastroenterol

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Section: Bringing Sarcopenia Assessment In Cirrhosis To the Bedsidementioning

confidence: 99%

Indian Journal of Gastroenterology—May–June 2023 — highlights

Bhatia

2023

Indian J Gastroenterol

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Myokines are associated with progression, course and mortality in alcohol‐associated liver disease

Kaur,

Verma,

Garg

et al. 2024

Aliment Pharmacol Ther

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SummaryBackground and AimsMyokines are the muscle‐derived hormones orchestrating muscle and systemic health. Their role in the progression of alcohol‐associated liver disease (ALD) remains elusive.MethodsThree‐hundred‐one patients across the spectrum of ALD including fatty liver (FL, N = 13), compensated cirrhosis (CC, N = 17), non‐acute decompensation (NAD, N = 95), acute decompensation (AD, N = 51) and acute‐on‐chronic liver failure (ACLF, N = 125) were recruited between 2021 and 2023. Plasma myostatin, decorin levels, nutritional status, handgrip strength (HGS), systemic inflammation, infection, ammonia, disease course and 30‐day mortality were recorded.ResultsPatients aged 48 years (IQR: 38–52) and 97.7% of males were enrolled. Myostatin was elevated while decorin was reduced in cirrhosis compared to without cirrhosis, and further in DC compared to CC (p < 0.001). A step‐wise increase in myostatin and reduction in decorin was observed transitioning from NAD to AD to ACLF (p < 0.001). Myostatin was further increased and decorin was reduced along with the grades and organ failures in AD and ACLF (p < 0.001, each). Baseline decorin (AUC: 0.797) and its combination with MELD (AUC: 0.814) predicted disease resolution in AD and ACLF. Although, both myostatin (aOR: 18.96) and decorin (aOR: 0.02) could predict mortality, decorin was independent (aOR: 0.04) and additive to MELD (AUC of MELD+logDecorin + logTLC + HE‐grade:0.815); p < 0.05 each. Myostatin increased and decorin reduced with inflammation, hyperammonaemia, malnutrition and HGS in AD and ACLF (p < 0.05, each).ConclusionMyokines are linked with malnutrition, fibrosis, systemic inflammation, organ failures, disease course and mortality in ALD. Decorin enhances the risk estimation of mortality of MELD in AD and ACLF. Therapeutic modulation of myokines is a potentially disease‐modifying target in ALD.

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Simple bedside tests of muscle strength and function correlate with computed tomography-skeletal muscle index for assessment of sarcopenia in cirrhosis

Cited by 2 publications

References 26 publications

Indian Journal of Gastroenterology—May–June 2023 — highlights

Indian Journal of Gastroenterology—May–June 2023 — highlights

Myokines are associated with progression, course and mortality in alcohol‐associated liver disease

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