Simple and Sensitive Determination of Sibutramine in Slimming Tea Beverages Using a Carbon Screen‐printed Electrode with Adsorptive Stripping Voltammetry

Abstract

The stimulant sibutramine is an anorexic agent found as an adulterant in natural products and multivitamins supplements used for weight‐loss. In this work, a carbon graphite screen‐printed electrode (SPE‐Gr) with adsorptive stripping pulse differential voltammetry (AdSDPV) is presented for the sensitive and simple detection of sibutramine in slimming tea beverages. The proposed electrochemical method shows a linear working range from 2.0 to 120 μM with a low LOD (0.3 μM) for sibutramine determination in slimming tea samples. The analytical performance of the SPE‐Gr with AdSDPV for sibutramine detection suggests its possible application as an easy, fast and low‐cost method to analyse adulterated tea samples with this stimulant at low levels (<0.1 %).

A simple cost-effective paper-based electrochemical device for detection of adulterated sibutramine in slimming products

“…The observed slope of (−0.058 ± 0.002) V/pH is equal to the Nernstian slope (−0.0591 V/pH) for one electron redox reaction. Thus, one amine group of sibutramine is oxidized with loss of one electron and one proton, as previously reported for a hanging mercury drop working electrode, 20 electro-reduced graphene oxide film modified glassy carbon electrode, 21 BDDE, 22 carbon graphite screen-printed electrode 23 and porous graphene ink-modified electrode. 24 In Fig.…”

“…17 Electroanalytical methods have also been reported for sibutramine detection including potentiometry 18,19 and voltammetry. 20–24…”

“…To overcome these limitations, a commercial carbon graphite screen-printed electrode (SPE-Gr), using samples on the microliter scale (100 μL), has been employed. 23 Sibutramine is detected by adsorptive stripping voltammetry, using either differential pulse voltammetry (DPV) or square wave voltammetry (SWV).…”

“…17 Electroanalytical methods have also been reported for sibutramine detection including potentiometry 18,19 and voltammetry. [20][21][22][23][24] With regard to the voltammetric technique, the traditional polarography, with the hanging mercury drop electrode (HDME) as a working electrode, was proposed for determination of sibutramine in beverages and pharmaceutical formulations. 20 Due to the toxicity of mercury, modied glassy carbon was reported as an alternative environmentally-friendly working electrode.…”

Dietary Supplements as Source of Unintentional Doping

“…Use of monoamine oxidase inhibitors (MAOIs) and sibutramine can lead to increase of blood pressure [122,123]. The unintentional intake of compound like sibutramine because of contaminated DS could affect overall health, the intake of medicines which are used for management of serious diseases, and a professional sport career [124][125][126].…”