Simple and Rapid Creation of Customized 3D Printed Bolus Utilizing iPhone X True Depth Camera

Abstract

pathways, including purine and pyrimidine synthesis, were inhibited after JQ-1 treatment. Finally, real-time PCR showed that GART, TYMS, MTR and DHFR were upregulated after MTX treatment. However, these genes were downregulated after combination with JQ-1. Conclusion: Our results indicated that the combination of DHFR inhibitor MTX and BRD4/MYC inhibitor JQ-1 could induce synthetic lethality in pancreatic cancer both in vitro and in vivo, by disturbing nucleotide biosynthesis pathways. This study may provide us with a promising strategy by using MTX and JQ-1, to increase the efficacy of chemotherapy of pancreatic cancer.