Simple and Fast Analytical Method for the Evaluation of the Encapsulation and Release Profile of Doxorubicin From Drug Delivery Systems

Rus, Iulia

doi:10.31925/farmacia.2021.4.6

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…Drug release from PLA electrospun mats measured using the voltammetric method yielded a slightly lower release percentage compared to UV-VIS. The different sensitivities of the two methods may explain the difference in the results [ 31 ]. The presence of Hap in the nanofiber matrix resulted in a more complex release.…”

Section: Resultsmentioning

confidence: 99%

“…The applicability of the method was studied for examining the release of piroxicam [ 29 ], doxorubicin [ 18 ], naproxen [ 21 ], selegiline [ 30 ], etc. DPV is also a remarkable alternative method for the qualitative and quantitative investigation of drug dissolution [ 23 , 31 , 32 ]. The oxidation of the analyte and the corresponding current production are caused by voltage pulses of increasing amplitudes.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers

Farkas

Marincaș

Barbu–Tudoran

et al. 2023

JFB

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Electrospun mats of PLA and PLA/Hap nanofibers produced by electrospinning were loaded with doxycycline (Doxy) through physical adsorption from a solution with initial concentrations of 3 g/L, 7 g/L, and 12 g/L, respectively. The morphological characterization of the produced material was performed using scanning electron microscopy (SEM). The release profiles of Doxy were studied in situ using the differential pulse voltammetry (DPV) electrochemical method on a glassy carbon electrode (GCE) and validated through UV-VIS spectrophotometric measurements. The DPV method has been shown to be a simple, rapid, and advantageous analytical technique for real-time measurements, allowing accurate kinetics to be established. The kinetics of the release profiles were compared using model-dependent and model-independent analyses. The diffusion-controlled mechanism of Doxy release from both types of fibers was confirmed by a good fit to the Korsmeyer–Peppas model.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers

Farkas

Marincaș

Barbu–Tudoran

et al. 2023

JFB

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“…Complexation of alginate with chitosan resulted in spectral displacement of carboxylic groups, with peak shifts from 1608 and 1429 cm −1 to 1618 and 1430 cm −1 , respectively. In the FT-IR spectrum of BSA/ALG/CHI MPs, the peak at 1528 cm −1 was indicative of N–H bending in amide groups in chitosan [ 58 ]. The corresponding peak in the range 1528–1534 cm −1 was attributed to C–N and C–N–H bending in chitosan [ 59 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

Physical, Chemical, and Biological Properties of Chitosan-Coated Alginate Microparticles Loaded with Porcine Interleukin-1β: A Potential Protein Adjuvant Delivery System

Chen

Lien

et al. 2022

IJMS

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We previously developed chicken interleukin-1β (IL-1β) mutants as single-dose adjuvants that induce protective immunity when co-administered with an avian vaccine. However, livestock such as pigs may require a vaccine adjuvant delivery system that provides long-lasting protection to reduce the need for successive booster doses. Therefore, we developed chitosan-coated alginate microparticles as a carrier for bovine serum albumin (BSA) or porcine IL-1β (pIL-1β) and assessed their physical, chemical, and biological properties. Electrospraying of the BSA-loaded alginate microparticles (BSA/ALG MPs) resulted in an encapsulation efficiency of 50%, and those MPs were then coated with chitosan (BSA/ALG/CHI MPs). Optical and scanning electron microscopy, zeta potential analysis, and Fourier transform infrared spectroscopy were used to characterize these MPs. The BSA encapsulation parameters were applied to ALG/CHI MPs loaded with pIL-1β, which were not cytotoxic to porcine fibroblasts but had enhanced bio-activity over unencapsulated pIL-1β. The chitosan layer of the BSA/ALG/CHI MPs prevented burst release and facilitated sustained release of pIL-1β for at least 28 days. In conclusion, BSA/ALG/CHI MPs prepared as a carrier for pIL-1β may be used as an adjuvant for the formulation of pig vaccines.

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“…The protective effects of EVOO and VCO in combination were shown to be superior against oxidative stress in multiple organs in doxorubicin-treated rats [13]. The study showed that the combination could prevent the development of myocardial injury after doxorubicin injection [14]. Accordingly, the present study aimed to examine the protective effect of an EVOO and VCO combination in a ratio of 1:1, 1:2 and 2:1 in ISO-treated rats.…”

Section: Introductionmentioning

confidence: 91%

The Cardioprotective Effect of Extra Virgin Olive Oil and Virgin Coconut Oil on Isoproterenol-Induced Myocardial Infarction in Rats

NADIAH¹

2023

FARMACIA

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Routine consumption of extra virgin olive oil (EVOO) and virgin coconut oil (VCO) may improve cardiovascular function. This study examined the cardioprotective effect of the combination of EVOO and VCO on isoproterenol-induced myocardial infarction in rats. Rats (n = 30) were divided into five groups: a healthy group, an isoproterenol group without treatment, and three treatment groups that were given an EVOO-VCO combination at 1:1, 1:2 and 2:1 (2 mL/200 g) orally for 14 days before injecting isoproterenol (100 mg/kg) for two consecutive days. After 24 hours, blood samples were taken to analyse cardiac biomarkers, and the heart was examined for histopathological changes. Isoproterenol injection caused a substantial increase in the creatine kinase-myocardial band, lactate dehydrogenase and aspartate aminotransferase levels. Pretreatment with an EVOO-VCO combination in all ratios significantly reduced these biomarker levels (p < 0.05). Myocardial damage was significantly reduced, especially with the EVOO-VCO combination of 2:1. In conclusion, the EVOO-VCO combination significantly reduced cardiac injury biomarker levels and improved myocardial structure in isoproterenol-induced myocardial infarction in rats. The EVOO-VCO combination of 2:1 was superior in preserving myocardial structure compared to the other ratios. RezumatConsumul uleiului de măsline extravirgin (EVOO) și a uleiului de cocos virgin (VCO) poate îmbunătăți funcția cardiovasculară. Acest studiu a examinat efectul cardioprotector al combinației de EVOO și VCO asupra infarctului miocardic indus de izoproterenol la șobolani. Șobolanii (n = 30) au fost împărțiți în cinci grupuri: un grup sănătos, un grup de izoproterenol fără tratament și trei grupuri de tratament cărora li s-a administrat o combinație de EVOO-VCO în proporție de 1:1, 1:2 și 2:1 (2 mL/200 g) pe cale orală timp de 14 zile înainte de injectarea de izoproterenol (100 mg/kg) timp de două zile consecutive. După 24 de ore, au fost prelevate probe de sânge pentru a analiza biomarkerii cardiaci, iar la nivelul inimii au fost examinate modificările histopatologice. Administrarea de izoproterenol a provocat o creștere substanțială a nivelurilor de creatin-kinază miocardică, lactat dehidrogenază și aspartat aminotransferază. Pretratarea cu o combinație EVOO-VCO, în toate proporțiile, a redus semnificativ aceste niveluri ale biomarkerilor (p < 0,05). Leziunile miocardice au fost diminuate, în special la administrarea combinației EVOO-VCO 2:1. În concluzie, asocierea EVOO-VCO a redus semnificativ nivelurile biomarkerilor cardiaci și a îmbunătățit structura miocardului în modelul experimental ales. Combinația EVOO-VCO de 2:1 a fost superioară în ceea ce privește conservarea structurii miocardice în comparație cu celelalte proporții.

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Simple and Fast Analytical Method for the Evaluation of the Encapsulation and Release Profile of Doxorubicin From Drug Delivery Systems

Cited by 5 publications

References 30 publications

Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers

Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers

Physical, Chemical, and Biological Properties of Chitosan-Coated Alginate Microparticles Loaded with Porcine Interleukin-1β: A Potential Protein Adjuvant Delivery System

The Cardioprotective Effect of Extra Virgin Olive Oil and Virgin Coconut Oil on Isoproterenol-Induced Myocardial Infarction in Rats

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