Simple Aggregation‐Induced Emission‐Based Multifunctional Fluorescent Dots for Cancer Therapy In Vitro

Lin, Xueran; Zhao, Junhao; Liu, Hongxing; Feng, Pengju; Yang, Fang; Chen, Tianfeng

doi:10.1002/asia.201901315

Cited by 2 publications

(5 citation statements)

References 40 publications

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“…Except for monitoring apoptosis, AIEgens can also serve as apoptosis inducers based on two mechanisms. ,− One is phototoxicity based on excessive cytotoxic ROS generated by AIEgens as photosensitizers (PSs) under light irradiation, and another is dark toxicity that can produce cytotoxicity without the participation of light.…”

Section: Apoptosismentioning

confidence: 99%

“…Another example of apoptosis was caused by the dark toxicity of AIEgens. An AIEgen called TPAPP-CHO formed nanoparticles (NPs) that could target lysosomes . In cytotoxicity assays, half-maximal inhibitory concentration (IC 50 ) value is a quantitative measure that indicates the effectiveness of a compound in inhibiting biological or biochemical function.…”

Section: Apoptosismentioning

confidence: 99%

Section: Apoptosismentioning

confidence: 99%

“…An AIEgen called TPAPP-CHO formed nanoparticles (NPs) that could target lysosomes. 62 In cytotoxicity assays, half-maximal inhibitory concentration (IC 50 ) value is a quantitative measure that indicates the effectiveness of a compound in inhibiting biological or biochemical function. The IC 50 in Figure 2 C, demonstrated significant cytotoxicity of the NPs against human U87 cancer cells.…”

Section: Apoptosismentioning

confidence: 99%

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Aggregation-Induced Emission Luminogens for Cell Death Research

Zuo

Shen

Sun

et al. 2022

ACS Bio Med Chem Au

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Cell death is closely related to various diseases, and monitoring and controlling cell death is a promising strategy to develop efficient therapy. Aggregationinduced emission luminogens (AIEgens) are ideal candidates for developing novel theranostic agents because of their intriguing properties in the aggregate state. The rational application of AIE materials in cell death-related research is still in its infancy but has shown great clinical potential. This review discussed the research frontier and our understanding of AIE materials in various subroutines of cell death, including apoptosis, necrosis, immunogenic cell death, pyroptosis, autophagy, lysosomedependent cell death, and ferroptosis. We hope that the new insights can be offered to this growing field and attract more researchers to provide valuable contributions.

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Section: Apoptosismentioning

confidence: 99%

Section: Apoptosismentioning

confidence: 99%

Section: Apoptosismentioning

confidence: 99%

Section: Apoptosismentioning

confidence: 99%

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Aggregation-Induced Emission Luminogens for Cell Death Research

Zuo

Shen

Sun

et al. 2022

ACS Bio Med Chem Au

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“…N-B-GQDs exhibit few side effects, favorable second NIR window imaging and effective transfer of NIR light to heat, resulting in possible biomedical applications of these QDs in phototherapy [ 192 ]. Fluorescent dots were found to dissociate within lysosomes after endocytic uptake and activate cellular apoptosis, triggering a cytotoxic effect in U-87 MG GBM cells [ 195 ]. Similarly, CNDQs were observed to distribute to lysosomes 6 h after incubation and also selectively target pediatric GBM cells, without affecting normal human embryonic kidney (HEK293) cells after conjugation with transferrin protein [ 196 , 197 , 198 ].…”

Section: Metal-based Nanoparticlesmentioning

confidence: 99%

Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update

2022

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Glioblastoma (GBM) is the most commonly diagnosed and most lethal primary malignant brain tumor in adults. Standard treatments are ineffective, and despite promising results obtained in early phases of experimental clinical trials, the prognosis of GBM remains unfavorable. Therefore, there is need for exploration and development of innovative methods that aim to establish new therapies or increase the effectiveness of existing therapies. One of the most exciting new strategies enabling combinatory treatment is the usage of nanocarriers loaded with chemotherapeutics and/or other anticancer compounds. Nanocarriers exhibit unique properties in antitumor therapy, as they allow highly efficient drug transport into cells and sustained intracellular accumulation of the delivered cargo. They can be infused into and are retained by GBM tumors, and potentially can bypass the blood–brain barrier. One of the most promising and extensively studied groups of nanostructured therapeutics are metal-based nanoparticles. These theranostic nanocarriers demonstrate relatively low toxicity, thus they might be applied for both diagnosis and therapy. In this article, we provide an update on metal-based nanostructured constructs in the treatment of GBM. We focus on the interaction of metal nanoparticles with various forms of electromagnetic radiation for use in photothermal, photodynamic, magnetic hyperthermia and ionizing radiation sensitization applications.

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Simple Aggregation‐Induced Emission‐Based Multifunctional Fluorescent Dots for Cancer Therapy In Vitro

Cited by 2 publications

References 40 publications

Aggregation-Induced Emission Luminogens for Cell Death Research

Aggregation-Induced Emission Luminogens for Cell Death Research

Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update

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